虾青素对去卵巢大鼠骨质疏松的改善作用OA

To investigate the improvement effect and mechanism of astaxanthin on osteoporosis in ovariectomized rats,eighty adult female SD rats were divided into a sham-operated group,a model group,and low-,medium-and high-dose astaxanthin groups(25,50,100 mg/kg).Bilateral ovariectomy was performed on all groups except the sham-operated group.After 8 weeks of oral gavage administration,relevant indicators were measured.The results showed that compared with the model group,the astaxanthin intervention groups exhibited increased bone mineral density,trabecular number and trabecular thickness(P＜0.05 or P＜0.01),and improvements were observed in pathological morphology including trabecular thinning,disruption,disorganized arrangement and structural ambiguity,and improved biomechanical indices such as elastic modulus,maximum load and yield load(P＜0.01);the contents of Ca,P,Fe and Zn in the femur were increased(P＜0.05 or P＜0.01),while the serum contents of C-terminal telopeptide of type Ⅰ collagen,procollagen type Ⅰ N-terminal propeptide,tumor necrosis factor-α,interleukin-1β and interleukin-6 and the activity of alkaline phosphatase were decreased(P＜0.05 or P＜0.01).The results indicated that astaxanthin could effectively ameliorate osteoporosis symptoms in ovariectomized rats,and its mechanism might be related to promoting bone mineral deposition,regulating bone turnover balance,and inhibiting inflammatory responses.