酵母中肌醇代谢与转运机制及其对发酵性能影响的研究进展OA
Advances in Metabolism and Transport Mechanisms of Inositol in Yeast and Their Effects on Fermentation Performance
肌醇是酵母细胞正常生长与增殖所必需的生长因子.在酵母细胞内,肌醇不仅是磷脂酰肌醇等细胞膜磷脂的前体物质,还通过生成一系列磷酸化衍生物参与细胞内信号转导等生理过程.酵母细胞主要通过肌醇-1-磷酸合成酶在胞内自主合成肌醇,并通过肌醇转运蛋白1等转运蛋白对外源肌醇进行摄取,这2种机制共同构成肌醇在酵母生长与代谢等生理活动中发挥作用的基础.本文介绍肌醇及其衍生物的生理功能、阐述酵母细胞内肌醇的合成途径,总结酵母对于肌醇的转运与利用的分子机制,并综述外源添加肌醇对不同酵母发酵性能的影响,旨在解析酵母的生长调控机制,为其发酵性能的提升提供理论依据.
Inositol is an essential growth factor for the normal growth and proliferation of yeast cells.Within yeast cells,inositol not only acts as a precursor of cell membrane phospholipids,including phosphatidylinositol,but also participates in physiological processes such as intracellular signal transduction by generating a series of phosphorylated derivatives.Yeast cells primarily synthesize endogenous inositol via inositol-1-phosphate synthase and take up exogenous inositol through transporters represented by inositol transporter 1(Itr1).These two mechanisms together form the basis for inositol to exert functions in physiological activities,including yeast growth and metabolism.This paper introduces the physiological functions of inositol and its derivatives,elaborates the biosynthesis pathway of inositol within yeast cells,summarizes the molecular mechanisms for inositol transport and utilization in yeast,and reviews the effects of exogenous inositol supplementation on fermentation performance of different yeasts,aiming to decipher the growth-regulation mechanisms of yeast and provide theoretical support for the improvement of fermentation performance.
张楠;刘琴琴;胡晓茵;陈丹;段坦;徐宁
湖北工业大学生命科学与健康工程学院,教育部工业发酵省部共建协同创新中心,湖北 武汉 430068湖北工业大学生命科学与健康工程学院,教育部工业发酵省部共建协同创新中心,湖北 武汉 430068咸宁市公共检验检测中心,湖北 咸宁 437100咸宁市公共检验检测中心,湖北 咸宁 437100湖北工业大学生命科学与健康工程学院,教育部工业发酵省部共建协同创新中心,湖北 武汉 430068湖北工业大学生命科学与健康工程学院,教育部工业发酵省部共建协同创新中心,湖北 武汉 430068
化学化工
肌醇酵母磷脂酰肌醇肌醇转运蛋白1发酵性能
inositolyeastphosphatidylinositolinositol transporter 1fermentation performance
《中国酿造》 2026 (9)
1-8,8
湖北省重点研发计划项目(2023BBB010)
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