胰脏酶解物改善脂多糖诱导的大鼠全身性炎症的研究OA

Inflammation is a critical biological response to harmful stimuli,but chronic inflammation can lead to severe diseases such as cardiovascular disorders,diabetes,and cancer.This study explores the anti-inflammatory potential of bioactive peptides derived from porcine pancreatic hydrolysate,in a lipopolysaccharide(LPS)-induced systemic inflammation model in rats.Porcine pancreas,rich in proteins,was enzymatically hydrolyzed using papain to generate bioactive peptides.Rats were divided into protective and therapeutic inter-vention groups,receiving low(0.19 g/kg),medium(0.57 g/kg),and high(0.95 g/kg)doses of pancreatic hydrolysate before or after LPS challenge.Blood samples were collected after treatment,and inflammatory factors were assayed using ELISA kits.Histological analysis of colon tissues was performed using H&E.Results demonstrated that pancreatic hydrolysate significantly reduced pro-inflammatory cyto-kine levels in a dose-dependent manner,with the high-dose group showing the most pronounced effects.Protective intervention was more effective than therapeutic intervention in mitigating inflammation and preserving colonic morphology.This study highlights the potential of porcine pancreatic hydrolysate as a natural anti-inflammatory agent,offering a sustainable solution for valorizing meat industry by-prod-ucts.