皱粒豌豆代餐粉对小鼠糖脂代谢紊乱及肠道菌群的影响OA

[Objective]To investigate the effects of wrinkled pea meal replacement powder on glucose and lipid metabolism disorders and gut microbiota.[Methods]A 12-week intervention experiment was conducted using a high-fat diet-fed mouse model.Changes in key indicators,including mouse phenotypes,blood biochemical parameters,histopathology,and gut microbial composition,were systematically monitored.[Results]Wrinkled pea meal replacement powder significantly reduced fasting blood glucose,area under the blood glucose curve,and serum levels of total cholesterol,triglycerides,and low-density lipoprotein cholesterol in high-fat-fed mice(P<0.05).It effectively alleviated hepatic steatosis,reduced serum alanine aminotransferase levels(P<0.05),and significantly mitigated hepatocyte damage.Additionally,consumption of wrinkled pea meal replacement powder significantly regulated gut microecological imbalance induced by a high-fat diet,increased gut microbial richness,decreased the Firmicutes/Bacteroidetes ratio,and increased the relative abundance of beneficial bacteria,including norank_f_Muribaculaceae,norank_o_Clostridia_UCG-014,and Bifidobacterium.[Conclusion]Wrinkled pea meal replacement powder has potential application value in improving glucose and lipid metabolism and regulating gut health.