微生物合成谷氨酸及其衍生物的研究进展OA
Research progress on biosynthesis of glutamic acid and its derivatives
谷氨酸是自然界含量最多的氨基酸之一,不仅参与组成生命体蛋白质,还是代谢网络上的中心节点物质,而谷氨酸及其衍生物(谷胱甘肽,L-茶氨酸,γ-氨基丁酸,谷氨酰胺,γ-聚谷氨酸)作为高值化生物制品被应用于食品、医药、农业和材料领域.随着合成生物学与系统代谢工程的发展,近年来,谷氨酸及其衍生物的生物合成技术已经不断产生突破.该文聚焦生物合成谷氨酸及其衍生物,系统梳理最新的重要研究进展,为相关领域的科研与产业化提供参考依据,对谷氨酸及其衍生物的发展前景进行展望.
Glutamic acid stands among the most abundant amino acids in nature.Beyond its role in composing biological proteins,it serves as a central node within metabolic networks.Glutamic acid and its derivatives(glutathione,L-theanine,γ-aminobutyric acid,glu-tamine,γ-polyglutamic acid),recognized as high-value biochemical products,find extensive applications across food,pharmaceutical,and materials industries.Recent advances in synthetic biology and systems metabolic engineering have driven significant breakthroughs in the biosynthesis of glutamic acid and its derivatives.This article focuses on the biosynthesis of glutamic acid and its derivatives,systemati-cally reviews the latest important research progress,provides reference for scientific research and industrialization in related fields,and looks forward to the development prospects of glutamic acid and its derivatives.
关丹;张迪;乔郅钠;尤甲甲;高敏杰;黄子洋;饶志明
江南大学生物工程学院,江苏无锡,214122江南大学生物工程学院,江苏无锡,214122江南大学生物工程学院,江苏无锡,214122江南大学生物工程学院,江苏无锡,214122江南大学生物工程学院,江苏无锡,214122江苏集萃未来食品技术研究所有限公司,江苏宜兴,214200江南大学生物工程学院,江苏无锡,214122
谷氨酸谷胱甘肽L-茶氨酸γ-氨基丁酸谷氨酰胺γ-聚谷氨酸
glutamic acidglutathioneL-theanineγ-aminobutyric acidglutamineγ-polyglutamic acid
《食品与发酵工业》 2026 (10)
407-419,13
国家重点研发计划项目(2021YFC2100900)江苏省前沿技术研发计划项目(BF2024012)国家自然科学基金项目(32471530)呼和浩特市"揭榜挂帅"项目(2023-揭榜挂帅-合-1)
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