基于网络药理学与分子对接研究不同药食同源植物提取液的降脂作用OA

To investigate the active components and hypolipidemic effects of medicinal and edible plants,this study evalu-ated eight species(foxtail millet,coix seed,tangerine peel,hawthorn,lotus leaf,mulberry leaf,cassia seed,and ginseng)through quantitative analysis of bioactive compounds,antioxidant capacity,and lipid metabolism-related functional indices,followed by cluster analysis and principal component analysis.Network pharmacology and molecular docking were further employed to identify potential hypolipidemic targets and pathways.Results demonstrated that lotus leaf exhibited the high-est flavonoid(75.81±2.87 mg RE/g DW)and total phenolic content(38.63±0.88 mg GAE/g DW),while hawthorn showed the highest total sugar content(67.54±1.13 mg DE/g DW).Notably,hawthorn displayed potent inhibitory effects on pancre-atic lipase(1.59±0.04 μg Orlistat/g DW),α-amylase(4.26±0.23 mg Acarbose/g DW),and α-glucosidase(87.46±0.97 μg Acarbose/g DW),along with superior sodium glycocholate binding capacity(59.24%)and cholesterol adsorption(9.57 mg/g).Network pharmacology revealed that hawthorn,lotus leaf,and coix seed primarily targeted lipid metabolism and atheroscle-rosis pathways,particularly through insulin resistance regulation.Molecular docking simulations revealed that key bioac-tive compounds(including stigmasterol,sitosterol,and rutin)exhibited strong binding affinities with core targets(INS,ALB,IL-6,etc.).These findings highlight hawthorn,lotus leaf,and coix seed as promising candidates for developing natu-ral hypolipidemic functional foods,supported by multi-omics evidence.