新型芳酰胺化合物的合成及抑菌活性研究OA

To develop novel fungicides suitable for the green control of fruit and vegetable diseases,12 nitro-containing aromatic amide compounds were designed and synthesized in this study.Their structures were confirmed by nuclear magnetic resonance(NMR),and their fungicidal activities against 4 common pathogenic fungi were evaluated.The results showed that most compounds exhibited moderate activity against Alternaria solani and Sclerotinia sclerotiorum,and weak activity against Botrytis cinerea and Rhizoctonia solani.Structure-activity relationship(SAR)analysis indicated that introduction of a 6-methyl group at the R2 position had a weak effect on antifungal activity,whereas addition of a nitro group at the R3 position generally led to decreased activity.Compounds I-2,I-8 and I-9 displayed favorable broad-spectrum activity,with inhibitory rates exceeding 50％ against four pathogens.Among them,compound I-9 showed the best activity,with inhibition rates of 75.75％ against S.sclerotiorum,which could be used as a lead compound for further optimization,providing solutions for the control of major diseases in fruits and vegetables and contributing to the green and sustainable development of the fruit and vegetable industry.