基于CiteSpace的母乳低聚糖研究热点和趋势分析及其生物合成研究进展OA
Analysis of Research Hotspots and Trends of Human Milk Oligosaccharides Based on CiteSpace and Advances in Biosynthesis
母乳低聚糖又称母乳寡糖(human milk oligosaccharides,HMOs),是母乳中独特的生物活性成分,近年来因其对婴幼儿健康的潜在有益机制而持续引发研究热潮.为系统阐明 HMOs领域的研究现状、热点和趋势,本研究基于 Web of Science 核心合集数据库,对 2000～2025年收录的 3282篇 HMOs研究文献展开多维度文献计量分析.首先,统计分析文献的年发文量趋势和在各类期刊的分布情况,然后运用 CiteSpace 绘制国家、机构、作者和关键词可视化图谱,识别核心研究国家、重要研究机构、高产作者群体以及研究热点主题.结果表明,HMOs领域正处于高速发展阶段,美国的科研机构和人员在该领域占据核心地位.值得关注的是,国内 HMOs研究呈现快速增长趋势,以江南大学为代表的科研机构在该领域取得显著进展.当前 HMOs领域的研究热点主要聚焦于两大方面:HMOs 与肠道菌群的互作机制研究和大肠杆菌细胞工厂合成 HMOs的技术开发.与化学合成法相比,酶法和微生物细胞合成法因其绿色可持续、高效且专一性强等优势,被广泛认为是更具发展潜力的 HMOs合成策略.随着 HMOs在婴幼儿配方奶粉和功能性食品中的应用需求持续增长以及合成生物学技术的不断突破,如何进一步提升 HMOs的产量与合成效率已成为当前亟待突破的关键技术瓶颈.因此,本文系统归纳总结 HMOs的生物合成方法,为HMOs领域的产业化进程和后续发展提供重要参考价值.
Human milk oligosaccharides(HMOs),as unique bioactive components in breast milk,have gained great scientific interest in recent years due to their potential beneficial mechanisms for infant health.To systematically elucidate the research status,hotspots,and developmental trends in the field of HMOs,a multidimensional bibliometric analysis of 3282 HMOs-related research articles indexed in the Web of Science Core Collection database was performed from 2000 to 2025.Firstly,quantitative analysis of the annual publication trends and journal distribution patterns are carried out.Then the visualization maps of country,institution,author,and keyword are generated to identify core research nations,significant research organizations,high-productivity author groups,and research hotspots through CiteSpace.The analytical results demonstrate that the field of HMOs is undergoing exponential growth,and the research institutions and scientific researchers in the United States occupy a core position.It is worth noting that the domestic research on HMOs is showing a rapid growth trend and Jiangnan University has driven significant research advances.Current research hotspots mainly focused on two directions,including the regulatory mechanism of HMOs interactions with intestinal microbiota,and the development of biosynthetic technologies for HMOs using Escherichia coli cell factories.Compared to chemical synthesis,enzymatic and microbial synthesis are widely recognized as more promising strategies for HMOs synthesis owing to their sustainability,efficiency,and high specificity.Given the surging demand for HMOs in infant formulas and functional foods along with continuous advances in synthetic biology,the enhancement of yield and synthesis efficiency of HMOs is urgent to overcome this technical bottleneck.Accordingly,biosynthesis methodologies for HMOs production are comprehensively categorized and evaluated,aiming to provide valuable insights to support industrialization and guide future developments in this field.
应晨辉;平颖奇;刘丹;金子恒;江正强
中国农业大学食品科学与营养工程学院,北京 100083||中原食品实验室,河南 漯河 462000中国农业大学食品科学与营养工程学院,北京 100083中国农业大学食品科学与营养工程学院,北京 100083河南中大恒源生物科技股份有限公司,河南 漯河 462000中国农业大学食品科学与营养工程学院,北京 100083||中原食品实验室,河南 漯河 462000
轻工纺织
母乳低聚糖CiteSpace文献计量学酶法合成大肠杆菌微生物细胞合成
human milk oligosaccharidesCiteSpacebibliometricsenzymatic synthesisEscherichia colimicrobial synthesis
《食品工业科技》 2026 (10)
512-525,14
国家自然科学基金(32172159).
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