基于酶的天麻酚类活性成分转化机制及产酶菌株应用研究进展OA

Gastrodia elata,a traditional and highly valued Chinese medicinal herb,contains major phenolic bioactive compounds(gastrodin,p-hydrox-ybenzyl alcohol and parishins),which exhibit multiple pharmacological activities including neuroprotection,anti-inflammation and antioxidant effects.However,these compounds suffer from low bioavailability in their natural state.In-depth investigation into biotransformation pathways of phenolic bioactive compounds in G.elata and promoting its transformation from a traditional herbal medicine into functional foods with enhanced stability,improved absorption,and better palatability is of great significance to the development of G.elata industry.In this paper,the pharmacological effects and action mechanisms of main phenolic bioactive compounds in G.elata were summarized,their pharmacokinetic characteristics were sorted out,the regulatory mechanism of β-glycosidase and esterase on the directed transformation of phenolic compounds in G.elata was expounded,the trans-formation pathway and enzymatic hydrolysis mechanism of the main phenolic transformation active components by enzymes were elaborated,and the enzymatic properties and application efficacy of strains producing β-glucosidase and esterase were further summarized,aiming to provide theoretical support and technical paradigms for developing high-value-added functional products derived from G.elata.