益生元调节老年肠道微生态及代谢的机制研究进展OA
Research Progress on the Mechanism of Prebiotics Regulating Intestinal Microecological and Metabolism in the Elderly
随着全球老龄化程度的不断加深,中国正面临日益严峻的人口老龄化挑战.在此背景下,老年人肠道微生态稳态逐渐成为食品营养与健康领域的研究热点.本文系统梳理了益生元通过调节肠道菌群结、改善菌群代谢物生成(短链脂肪酸、胆汁酸等)、修复肠道屏障等途径调控肠道稳态的作用机制,并总结了其在肥胖、高血糖、高血脂等老年常见代谢性疾病干预中的潜在价值.同时,对不同类型益生元(如菊粉与低聚果糖)的作用效果及分子机制进行了比较分析.然而,目前益生元在老年人群体中的应用机制尚不完全明确,整体效应仍需深入验证.未来应重点关注益生元与其他膳食成分或药物联合干预的协同效应,积极开发针对老年人群生理特点的新型、高效益生元产品,以提升营养干预策略的精准性与实用性.
With the increasing prevalence of global aging,China is confronted with a significant challenge posed by an aging population.The intestinal microecological health of the elderly has emerged as a critical research focus.This paper comprehensively examines the beneficial impacts of prebiotics on intestinal barrier function and immune modulation.These effects are attained through the stimulation of beneficial bacteria growth,the suppression of pathogenic bacteria proliferation,and the augmentation of short-chain fatty acid synthesis.Additionally,the paper summarizes the potential of prebiotics in managing prevalent metabolic disorders in the elderly,including obesity,hyperglycemia,and hyperlipidemia.Moreover,a comparative assessment is carried out on the action features of various prebiotics,such as inulin and fructooligosaccharides.At present,the application mechanisms of prebiotics in the elderly population are not fully comprehended,and their overall effectiveness requires further investigation.Future studies place emphasis on investigating the synergistic actions of prebiotics combined with other dietary or pharmacological interventions and accelerate the development of innovative,highly efficient prebiotic products specifically designed for the elderly,thus enhancing the accuracy and applicability of nutritional intervention approaches.
LIU Wenjun;WANG Pan;WANG Yubin;WANG Dan;ZHAO Wenting;ZHAO Yuanyuan;ZHAO Xiaoyan;ZHANG Chunhong
College of Food Science,Shenyang Agricultural University,Shenyang 110866,Chin||Institute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaInstitute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaInstitute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaInstitute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaInstitute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaInstitute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaCollege of Food Science,Shenyang Agricultural University,Shenyang 110866,Chin||Institute of Agri-food Processing and Nutrition,Beijing Academy of Agriculture and Forestry Sciences,Beijing Key Laboratory of Agricultural Products of Fruits and Vegetables Preservation and Processing,Key Laboratory of Vegetable Postharvest Processing,Ministry of Agriculture and Rural Affairs,Beijing 100097,ChinaCollege of Food Science,Shenyang Agricultural University,Shenyang 110866,Chin
轻工纺织
益生元老年肠道微生态代谢性疾病菌群结构菌群代谢物
prebioticsintestinal microecology in the elderlymetabolic diseasesmicrobiota structuremicrobiota metabolites
《食品工业科技》 2026 (2)
448-459,12
北京市农林科学院优秀青年基金(YXQN202202)北京市农林科学院科技创新能力建设专项(KJCX20240402,KJCX20240507)北京市农林科学院青年英才引进基金(130110114).
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