Baihe Dihuang decoction(百合地黄汤)activates cannabinoid type 2 receptor to regulate microglial polarization and alleviate anxiety-like behavior in chronic restraint stress miceOA
Baihe Dihuang decoction(百合地黄汤)activates cannabinoid type 2 receptor to regulate microglial polarization and alleviate anxiety-like behavior in chronic restraint stress mice
LUO Qiaoyun;HAN Yuanshan;LIU Yang;TANG Lin;WANG Tianyu;WANG Yuhong;ZHAO Hongqing
School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,ChinaDrug Clinical Research Center,the First Hospital,Hunan University of Chinese Medicine,Changsha 410007,ChinaAcademy of Chinese Medical Sciences/Science & Technology Innovation Center,Hunan University of Chinese Medicine,Changsha 410208,ChinaPharmaceutical Preparation Center,the first affiliated Hospital,Hunan University of Chinese Medicine,Changsha 410007,ChinaSchool of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,ChinaAcademy of Chinese Medical Sciences/Science & Technology Innovation Center,Hunan University of Chinese Medicine,Changsha 410208,ChinaAcademy of Chinese Medical Sciences/Science & Technology Innovation Center,Hunan University of Chinese Medicine,Changsha 410208,China
receptor,cannabinoid,CB2neuroinflammatory diseasesanxiety disordersanti-anxiety agentsmicroglial polarizationBaihe Dihuang decoction
receptor,cannabinoid,CB2neuroinflammatory diseasesanxiety disordersanti-anxiety agentsmicroglial polarizationBaihe Dihuang decoction
《中医杂志（英文版）》 2026 (4)
798-808,11
Supported by the National Natural Science Foundation of China:Mechanism Study of Baihe Dihuang Decoction in Ameliorating Neural Pathway Injury of Basolateral Amygdala-Ventral Hippocampus in Anxious Depression via Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase 2(No.82104836)Natural Science Foundation of Hunan Province:Study on the Mechanism of Anxiolytic Mechanism of Baihe Dihuang Decoction by Activating Cannabinoid Type 2 Receptor to Regulate the Polarization Phenotype of Microglia(No.2023JJ60482)Mechanism Study of Baihe Dihuang Decoction in Improving Synaptic Homeostasis of Basolateral Amygdala-ventral Hippocampus in Anxious Depression by Regulating Microglial Function via Cannabinoid Type 2 Receptor(No.2026JJ50265)Scientific Research Project of Hunan Provincial Department of Education:Mechanism of Excitatory/Inhibitory Imbalance of Spiny Neurons in Basolateral Amygdala to Nucleus Accumbens Neural Circuit Inducing Anxiety and Intervention Research of Baihe Shugan Anshen Tablets(No.23B0391)Open Fund of National Key Laboratory Cultivation Base of Chinese Medicinal Powder &Innovative Medicinal Jointly Established by Province and Ministry:Mechanism of Anxiolytic Neural Circuitry of Baihe Jielü Anshen Granules was Studied Based on Basolateral Amygdala to Nucleus Accumbens Neuronal Excitation/Inhibition Imbalance(No.25PTKF1002)Science and Technology Talent Promotion Project of Hunan Province:Young and Talented Science and Technology Talent Development Program(No.2023TJ-N22)
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