清肺化纤汤对气阴两虚型肺间质纤维化患者肺功能、氧化应激和生存质量的影响OA
Effects of Qingfei Huaxian Decoction on Pulmonary Function,Oxidative Stress,and Quality of Life in Patients of Interstitial Pulmonary Fibrosis with Qi-Yin Deficiency Pattern
目的 观察清肺化纤汤治疗气阴两虚型肺间质纤维化的临床疗效,以及对患者肺功能、氧化应激和生存质量的影响.方法 选取符合纳入标准的气阴两虚型肺间质纤维化患者90例,依据随机数字表随机分对照组和治疗组,每组各45例.对照组给予常规西医治疗,治疗组在对照组用药基础上给予清肺化纤汤治疗,两组均治疗12周.治疗前后对中医症状进行评分,评价临床症状改善情况;应用血气分析仪和肺功能仪测定肺功能指标,包括用力肺活量(FVC)、一氧化碳弥散量(DLCO)、动脉血氧分压(PaO2)、第一秒用力呼气量(FEV1);比色分析法和放射免疫法测定氧化应激和肺纤维化指标,包括超氧化物歧化酶(SOD)、丙二醛(MDA),血清黏连蛋白(LN)和透明质酸(HA);六分钟步行试验(6MWD)测定肺部功能及活动耐力;圣乔治呼吸问卷(SGRQ)评价患者治疗前后生存质量,并比较临床疗效.结果 治疗组总有效率84.4%(38/45),显著高于对照组62.2%(28/45)(P<0.01).与治疗前比较,两组治疗后中医各症状积分、SGRQ评分和MDA、LN、HA水平均明显降低(P<0.05),DLCO、FEV1、FVC、PaO2、6MWD、SOD水平升高(P<0.05),且治疗组中医各症状积分、SGRQ评分和MDA、LN、HA水平低于对照组(P<0.01),DLCO、FEV1、FVC、PaO2、SOD水平高于对照组(P<0.01).结论 清肺化纤汤有助于恢复气阴两虚型肺间质纤维化患者肺功能,缓解不适症状,改善氧化应激状态,提高临床治疗效果和生存质量.
Objective To observe the clinical efficacy of Qingfei Huaxian Decoction in treating interstitial pulmonary fibrosis with qi-yin deficiency pattern,as well as its effect on patients'pulmonary function,oxidative stress and quality of life.Methods Ninety patients of interstitial pulmonary fibrosis with qi-yin deficiency pattern who met the inclusion criteria were recruited and randomly divided into a control group and a treatment group using a random number table,with forty-five patients in each group.The control group was treated with conventional Western medicine treatment.In addition to this conventional treatment,treatment group was administered Qingfei Huaxian Decoction.The treatment duration was 12 weeks for both groups.Before and after treatment,traditional Chinese medicine(TCM)symptom scores were employed to assess the improvement in clinical symptoms;pulmonary function parameters were measured using a blood gas analyzer and a spirometer,including forced vital capacity(FVC),diffusing capacity for carbon monoxide(DLCO),arterial partial pressure of oxygen(PaO2)and forced expiratory volume in 1 second(FEV1);oxidative stress and pulmonary fibrosis markers were measured using colorimetric assays and radioimmunoassays,including superoxide dismutase(SOD),malondialdehyde(MDA),serum laminin(LN),and hyaluronic acid(HA);6-minute walking distance(6MWD)was employed to measure pulmonary function and exercise tolerance;and the St.George's Respiratory Questionnaire(SGRQ)was used to assess the quality of life.Clinical efficacy was compared between the two groups.Results The total effective rate of the treatment group was 84.4%(38/45),which was significantly higher than 62.2%(28/45)in the control group(P<0.01).Compared with the baseline,both groups showed significant reductions in TCM symptom scores,SGRQ scores,and levels of MDA,LN and HA after the treatment(P<0.05),alongside significant increases in DLCO,FEV1,FVC,PaO2,6MWD,and SOD levels(P<0.05).Notably,the treatment group demonstrated significantly lower TCM symptom scores,SGRQ scores,and levels of MDA,LN,and HA(P<0.01),but higher values of DLCO,FEV1,FVC,PaO2,and SOD compared to the control group(P<0.01).Conclusion Qingfei Huaxian Decoction can help restore pulmonary function,alleviate discomfort symptoms,ameliorate oxidative stress,enhance clinical efficacy,and improve quality of life in patients of interstitial pulmonary fibrosis with qi-yin deficiency pattern.
王丽东;丁星;苏克雷;马永宾;蒋和平
常州市金坛第一人民医院,江苏 常州 213200常州市金坛第一人民医院,江苏 常州 213200江苏省中西医结合医院,江苏 南京 210000常州市金坛第一人民医院,江苏 常州 213200常州市金坛第一人民医院,江苏 常州 213200
肺间质纤维化清肺化纤汤肺功能生存质量气阴两虚
Interstitial pulmonary fibrosisQingfei Huaxian DecoctionPulmonary functionQuality of lifeQi-yin deficiency
《中医药信息》 2026 (10)
65-69,5
常州市卫健委科技项目(ZD202352)
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