加味麻杏二三汤对痰浊阻肺型慢性阻塞性肺疾病急性加重期患者的影响OA
Effects of Modified Maxing Ersan Decoction on Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease of Turbid Phlegm Obstructing Lung Pattern
目的 探究加味麻杏二三汤联合常规西药治疗对痰浊阻肺型慢性阻塞性肺疾病急性加重期(AECOPD)患者血气分析、肺功能及血清炎症因子水平的影响.方法 选取符合纳入标准的206例痰浊阻肺型AECOPD患者开展前瞻性临床研究,依据随机数字表随机分为对照组和研究组,每组103例,去除脱落病例后,最终研究组完成101例、对照组完成99例.对照组给予常规西医治疗,研究组在常规西医治疗基础上口服加味麻杏二三汤,两组均治疗2周.观察两组中医症状评分、肺功能指标[用力肺活量(FVC)、第一秒用力呼气容积(FEV1)、FEV1/FVC]、血气分析指标[动脉血氧分压(PaO2)、二氧化碳分压(PaCO2)、血氧饱和度(SaO2)]、血清炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)及肿瘤坏死因子-α(TNF-α)]的变化情况,并比较两组的临床疗效和安全性指标.结果 研究组临床总有效率96.04%(97/101),对照组临床总有效率87.88%(87/99),研究组临床疗效更优(P<0.05).与治疗前比较,两组治疗后中医症状评分、PaCO2、IL-6、IL-10、CRP、TNF-α水平均降低(P<0.05),FVC、FEV1、PaO2、SaO2均升高(P<0.05),且研究组上述指标的改善情况优于对照组(P<0.05).两组不良反应比较,差异无统计学意义(P>0.05).结论 加味麻杏二三汤联合常规西药治疗痰浊阻肺型AECOPD患者安全有效,改善中医症状、肺功能与血气分析指标,减轻炎症反应.
Objective To investigate the effect of modified Maxing Ersan Decoction combined with conventional Western medicine on blood gas analysis,pulmonary function and serum inflammatory factor levels in patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD)of turbid phlegm obstructing lung pattern.Methods A prospective clinical study was conducted on 206 patients with AECOPD of turbid phlegm obstructing lung pattern who met the inclusion criteria.They were randomly divided into a study group and a control group using a random number table,with 103 cases in each group.After excluding dropouts,101 cases in the study group and 99 cases in the control group completed the trial.The control group received conventional Western medicine treatment,while the study group was additionally administered modified Maxing Ersan Decoction orally on the basis of conventional Western medicine.Both groups were treated for 2 weeks.Traditional Chinese medicine(TCM)symptom scores,pulmonary function indicators[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],blood gas analysis indicators[arterial partial pressure of oxygen(PaO2),partial pressure of carbon dioxide(PaCO2),blood oxygen saturation(SaO2)],and serum inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),interleukin-10(IL-10),and tumor necrosis factor-α(TNF-α)]were observed in both groups.Clinical efficacy and safety indicators were also compared between the two groups.Results The overall clinical efficacy rate was 96.04%(97/101)in the study group and 87.88%(87/99)in the control group,indicating superior clinical efficacy in the study group(P<0.05).Compared with before treatment,TCM symptom scores,PaCO2,IL-6,IL-10,CRP,and TNF-α levels were decreased(P<0.05),while FVC,FEV1,PaO2,and SaO2 were increased in both groups after treatment(P<0.05).The improvement of the above indicators in the study group was superior to that in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Modified Maxing Ersan Decoction combined with conventional Western medicine is safe and effective in the treatment of patients with AECOPD of turbid phlegm obstructing lung pattern.It can improve TCM symptoms,pulmonary function and blood gas analysis indicators,and alleviate inflammatory responses.
杨闯;邹冬侠;纪兆放;王跃;杜芳;董志明
宿迁中西医结合医院,江苏 宿迁 223800宿迁中西医结合医院,江苏 宿迁 223800宿迁中西医结合医院,江苏 宿迁 223800宿迁中西医结合医院,江苏 宿迁 223800宿迁中西医结合医院,江苏 宿迁 223800宿迁中西医结合医院,江苏 宿迁 223800
慢性阻塞性肺疾病急性加重期加味麻杏二三汤痰浊阻肺型血气分析肺功能炎症因子
Chronic obstructive pulmonary diseaseAcute exacerbationModified Maxing Ersan DecoctionTurbid phlegm obstructing ling patternBlood gas analysisPulmonary functionInflammatory factor
《中医药信息》 2026 (10)
59-64,6
宿迁市指导性科技计划项目(ZD2025J094)
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