从"脏虚营浊"理论探讨线粒体质量控制失衡介导膝骨关节炎滑膜炎-软骨退变轴的病机与治疗OA

Knee osteoarthritis(KOA)falls within the categories of"Bi syndrome"and"knee Bi"in traditional Chinese medicine(TCM).Its occurrence and progression are closely associated with synovial inflammation,cartilage degeneration,and imbalance of the local joint microenvironment.This study elucidates the pathophysiological mechanisms and therapeutic strategies for the mitochondrial quality control imbalance-mediated synovitis-cartilage degeneration axis in KOA,interpreted through the lens of the theory of"Zang Deficiency and Ying Turbidity".It is believed that imbalance in mitochondrial quality control participates in energy metabolism disorders,oxidative stress,inflammatory responses,and cartilage matrix destruction in KOA.Grounded in the Huangdi Neijing concepts of Zang-Fu viscera,nutritive-defensive qi and blood,clarity-turbidity ascent-descent,and meridian nourishment of bone and sinew,this study proposes that the theory of"Zang Deficiency and Ying Turbidity"can account for the KOA pathogenetic sequence:"root deficiency,turbid pathogen generation,collateral obstruction,failure of bone-sinew nourishment".In this model,Zang deficiency constitutes the root cause,Ying turbidity accumulation represents the pathological transformation,and chronic unresolved turbidity leads to impaired collateral patency and eventual deprivation of nutritional support to bone and cartilage.