枢机针法针刺联合艾司唑仑治疗失眠症的疗效及免疫机制研究OA
Therapeutic Effect and Immune Mechanism of Pivot Acupuncture Combined with Estazolam in the Treatment of Insomnia
目的:研究枢机针法针刺联合艾司唑仑治疗失眠症的疗效及免疫机制.方法:选取 2023 年8 月—2025 年1 月广州中医药大学深圳医院针灸科收治的失眠症患者80 例,参照随机数字表法分为常规组与治疗组,每组40 例.常规组采用艾司唑仑治疗,治疗组采用枢机针法针刺联合艾司唑仑治疗.比较两组临床疗效,对比两组治疗前后中医证候积分、睡眠结构(总睡眠时间、睡眠效率、非快速眼动1、2、3 期和快速眼动期时间占总睡眠时间的百分比)、血清神经递质水平(血清γ-氨基丁酸、谷氨酸)、机体免疫功能(血清白介素-6、白介素-1β、肿瘤坏死因子α)的变化.结果:治疗组与常规组治疗有效率分别为90.00%(36/40)、65.00%(26/40),治疗组优于常规组(P<0.01).两组治疗后总睡眠时间、睡眠效率、非快速眼动3 期、快速眼动期时间占总睡眠时间的百分比、血清γ-氨基丁酸、谷氨酸含量均高于治疗前(P<0.05),各项中医证候积分、非快速眼动1、2 期及血清白介素-6、白介素-1β、肿瘤坏死因子α水平均低于治疗前(P<0.05).治疗组上述指标均优于常规组(P<0.05).结论:枢机针法针刺联合艾司唑仑治疗失眠症的疗效明显,推测可能与其通过改善患者睡眠结构,调节血清神经递质水平,提高机体免疫功能等机制有关.
Objective:To study the efficacy and immune mechanism of pivot acupuncture combined with estazolam in the treatment of insomnia.Methods:80 patients diagnosed with insomnia after examination in the Department of Moxibustion of Shenzhen Hospital of Guangzhou University of Chinese Medicine were selected,and the enrollment time was within the range from August 2023 to January 2025.According to the random number table method,they were divided into the conventional group(40 cases,estazolam)and the treatment group(40 cases,pivot acupuncture+estazolam).The clinical efficacy was compared,and the changes in sleep structure(total sleep time,sleep efficiency,the percentages of non-rapid eye movement stage 1,2,and 3 and rapid eye movement stage time in total sleep time),serum neurotransmitter levels(serum γ-aminobutyric acid,glutamic acid),and immune function of the body(serum interleukin-6,interleukin-1 β,tumor necrosis factor α)before and after treatment were also compared.Results:The treatment group had higher effective rates(90.00%vs.65.00%)(P<0.01).After treatment in both groups,the total sleep time,sleep efficiency,the percentage of non-rapid eye movement stage 3 and rapid eye movement stage time to the total sleep time,the contents of serum γ-aminobutyric acid and glutamic acid showed higher values than those before treatment,while scores of TCM syndromes,the levels of non-rapid eye movement stage 1 and 2,serum interleukin-6,interleukin-1 β and tumor necrosis factor α showed lower values(P<0.05).After treatment,the treatment group showed higher total sleep time,sleep efficiency,non-rapid eye movement stage 3,the percentage of rapid eye movement stage time to total sleep time,and the contents of serum gamma-aminobutyric acid and glutamic acid,while lower scores of TCM syndromes levels of non-rapid eye movement stage 1 and 2,serum interleukin-6,interleukin-1 β,and tumor necrosis factor α(P<0.05).Conclusions:The therapeutic effect of pivot acupuncture combined with estazolam in the treatment of insomnia is obvious.It is speculated that it may be related to its mechanisms such as improving the sleep structure of patients,regulating the levels of serum neurotransmitters,and enhancing the immune function of the body.
胡翀妮;刘毅;崔星;谢宇锋;周遵明
广州中医药大学深圳医院(福田),广东 深圳 518034广州中医药大学深圳医院(福田),广东 深圳 518034广州中医药大学深圳医院(福田),广东 深圳 518034广州中医药大学深圳医院(福田),广东 深圳 518034广州中医药大学深圳医院(福田),广东 深圳 518034
医药卫生
枢机针法针刺艾司唑仑失眠症睡眠结构免疫机制临床疗效
Pivot acupunctureEstazolamInsomniaSleep structureImmune mechanismClinical efficacy
《中医药学报》 2026 (10)
59-63,5
广东省中医药局科研项目(20271130)深圳市福田区卫生健康系统科研项目(FTWS2022066,FTWS2025042)
评论