基于多维度药效学比较的香附十三制法炮制增效作用优势研究OA

Objective:To compare the superior processing synergistic efficacy of Thirteen-processed Cyperi Rhizoma with Xiushan characteristic processing technology,and to provide a research basis for the modern industrial improvement of regional characteristic processed TCM products.Methods:On the basis of inheriting the unique Xiushan processing technology for Thirteen-processed Cyperi Rhizoma,multiple rat models of traditional Chinese medicine syndromes were established,including primary dysmenorrhea,threatened abortion with uterine hemorrhage,and liver depression,qi stagnation and blood stasis.The therapeutic advantages of this regional characteristic processed product were comprehensively compared with those of clinically commonly-used processed products in modern practice and representative processed varieties recorded in successive dynasties.Results:Thirteen-processed Cyperi Rhizoma significantly reduced the writhing times(P<0.05,P<0.01),decreased the uterine organ coefficient(P<0.05,P<0.01),and lowered serum levels of PGF2α,GnRH and LH(P<0.05)in mice with primary dysmenorrhea.It also remarkably relieved vaginal bleeding volume and reduced FSH and LH levels(P<0.05)in the rat model of threatened abortion with uterine hemorrhage.In addition,it significantly decreased whole blood high-,medium-and low-shear viscosity,plasma viscosity,as well as serum ALT and AST levels(P<0.05)in rats with liver depression,qi stagnation and blood stasis.Conclusion:As an inheritance of local characteristic processing technology,Thirteen-processed Cyperi Rhizoma is insufficient in repairing substantial organic lesions.However,it presents prominent processing potentiating effects in the intervention and treatment of primary dysmenorrhea,threatened abortion with uterine hemorrhage,and liver depression,qi stagnation and blood stasis.It can be regarded as a distinctive processed medicinal material for further in-depth research and modern industrial transformation and optimization.