帕金森病疼痛与中医证素相关性研究OA

Objective To explore the clinical features of Parkinson's disease(PD)with pain and their correlation with Chinese medicine(CM)elements.Methods Clinical data from 150 PD patients were analyzed,with 92 cases in the pain group and 58 cases in the non-pain group.CM pattern element distributions were compared between groups,and their associations with pain occurrence,type,and intensity were evaluated.Results The prevalence of pain in PD patients was 61.3％.PD patients with pain were older(P=0.011),had longer disease duration(P＜0.001),higher daily levodopa equivalent doses(P=0.006),and more severe anxiety(P=0.008)compared to those without pain.Common pattern elements in the pain group included qi deficiency(76.1％),yin deficiency(66.3％),Shen deficiency(64.1％),and blood deficiency(62.0％).Compared with the non-pain group,the pain group showed higher incidence of blood deficiency,marrow depletion,yang hyperactivity,blood stasis,and qi stagnation,but lower Shen deficiency incidence(P＜0.05).Yang hyperactivity(OR=2.779,P=0.022)and qi stagnation(OR=2.879,P=0.017)were independent risk factors for PD pain,while Shen deficiency was a protective factor(OR=0.384,P=0.039).Blood deficiency and blood stasis exhibited a negative interaction(OR=0.101,P=0.023).Qi deficiency,marrow depletion,and phlegm-turbidity were positively associated with dystonia pain(P＜0.05),whereas qi stagnation was negatively correlated with musculoskeletal pain(P＜0.05).Internal heat,blood stasis,and Gan wind were positively correlated with pain intensity(P＜0.05).Conclusions Qi deficiency,yin deficiency,Shen deficiency,and blood deficiency are major CM pattern elements in PD with pain.Yang hyperactivity and qi stagnation increase pain risk,while Shen deficiency may reduce it.Blood deficiency and blood stasis interact negatively regarding pain in PD.Dystonic pain is closely associated with qi deficiency,marrow depletion,and phlegm-turbidity.Pain severity correlates with internal heat,blood stasis,and Gan wind.(International Traditional Medicine Clinical Trial Registry No.ITMCTR2025001045)