基于复杂网络分析针灸治疗干眼的临床处方规律及证-穴应用特点OA

Objective:To analyze the clinical prescription patterns and syndrome-acupoint application characteristics of acupuncture in treatment of dry eye disease using complex network analysis,and to provide a theoretical reference for clinical acupuncture prescription selection and syndrome differentiation-based acupoint selection.Methods:Chinese and English databases were searched for clinical studies on acupuncture treatment for dry eye disease,including CNKI,Wanfang Data,VIP Database,SinoMed,PubMed,Web of Science,Ebsco,and Ovid.Literature was screened according to the predefined inclusion and exclusion criteria.After data standardization,the extracted information was imported into Microsoft Excel 2019 to establish a database.Association rule analysis was performed using SPSS Modeler 18.0,while complex network k-core hierarchical analysis and community analysis were conducted using Gephi 0.9.7 software.Results:A total of 188 Chinese and English articles were included,from which 208 acupuncture prescriptions were extracted,involving 108 acupoints with a cumulative frequency of 1,884 applications.Acupoint selection was primarily based on the 14 meridian acupoints,with additional involvement of extraordinary acupoints and auricular acupoints.The selected acupoints were mainly distributed in head and facial regions.Association rule analysis and co-occurrence network analysis demonstrated that the strongest correlation was observed between Cuanzhu(BL2)and Jingming(BL1).Complex network k-core hierarchical analysis and community analysis identified 32 core acupoints and 3 core communities.Conclusion:In treatment of dry eye disease with acupuncture,acupoint prescriptions should be selected according to the patient's specific condition,with therapeutic principles focusing on tonifying deficiency,comprehensive regulation,or calming the mind.Syndrome differentiation mainly centers on Lung,Liver,Spleen,and Kidney,with targeted acupoint selection accordingly.These findings may provide a theoretical reference for clinical acupuncture prescription selection and syndrome differentiation-based acupoint application.