交泰针法联合聪脑通络针法治疗卒中后认知障碍的临床研究OA

Objective:To investigate the clinical efficacy of Jiaotai acupuncture combined with Congnao Tongluo acupuncture in treatment of post-stroke cognitive impairment(PSCI).Methods:A total of 115 patients with PSCI were randomly assigned to the observation group(n=57)and the control group(n=58).Patients in the observation group received Jiaotai acupuncture combined with Congnao Tongluo acupuncture,whereas those in the control group received Congnao Tongluo acupuncture alone.During the study,7 patients in the observation group and 8 patients in the control group withdrew.Consequently,50 patients in each group completed the study and were included in the efficacy analysis.The total effective rate was compared between the two groups.A comprehensive evaluation was conducted before the treatment and one month after the treatment based on cognitive function,Chinese Stroke Scale(CSS),activities of daily living,P300 auditory event-related potentials,cerebral hemodynamic parameters,inflammatory cytokine levels,oxidative stress status,and serum biomarkers of neurological function.Results:The total effective rate was 94.00％(47/50)in the observation group,which was significantly higher than 80.00％(40/50)in the control group(P＜0.05).Compared with the control group,the observation group demonstrated significantly greater improvements in cognitive function,CSS score,activities of daily living,P300 event-related potential parameters,cerebral hemodynamic parameters,inflammatory cytokine levels,oxidative stress indices,and serum biomarkers of neurological function(P＜0.05).Conclusion:Jiaotai acupuncture combined with Congnao Tongluo acupuncture may exert synergistic therapeutic effects by suppressing neuroinflammation,alleviating oxidative stress,improving cerebral perfusion,and promoting neural repair and neuroplasticity.These combined effects may contribute to improvements in cognitive function,activities of daily living,and neurological deficits in patients with PSCI.