毫火针浅刺联合自血疗法治疗老年皮肤瘙痒症的疗效及对血清免疫功能的影响OA

Objective:To investigate the clinical efficacy of superficial fire-needle acupuncture combined with autohemotherapy in treatment of senile pruritus and its impact on serum immune function indicators.Methods:A total of 126 patients with senile pruritus were prospectively enrolled into the study.Patients were randomly assigned to the control group and the observation group,with 63 patients in each group.The control group received conventional Western medical treatment;on which basis,the observation group also received superficial fire-needle acupuncture combined with autohemotherapy.After 3 weeks of treatment,clinical efficacy,TCM syndrome scores,skin lesion healing scores,frequency of pruritus episodes,sleep quality scores,serum immune function indicators,quality of life scores,and the incidence of adverse events were evaluated and compared between the two groups.Results:After the treatment,the total effective rate was 93.65％(59/63)in the observation group,which was significantly higher than 79.37％(50/63)in the control group(P＜0.05).Compared with the control group,the observation group showed significantly higher serum levels of IL-4 and IL-12(P＜0.05).The observation group exhibited significantly lower TCM symptom scores,secondary skin lesion scores,frequency of pruritus episodes,EOS levels,PSQI scores,ESS scores,and DLQI scores than the control group(P＜0.05).Conclusion:Superficial fire-needle acupuncture combined with autohemotherapy effectively improves the clinical outcomes and exerts significant immunomodulatory effects on serum immune function indicators in patients with senile pruritus.