生肌玉红膏联合富血小板血浆注射治疗糖尿病足溃疡的临床研究OA

Objective:To evaluate the clinical efficacy of Shengji Yuhong ointment combined with platelet-rich plasma(PRP)injection in the treatment of diabetic foot ulcers(DFU).Methods:In this prospective trial,135 DFU patients ad-mitted between January 2022 and January 2025 were enrolled and randomly assigned via a random number table to either a control group(n=67)receiving standard care,or an observation group(n=68)receiving additional therapy with Shengji Yuhong ointment and PRP injection.Both groups underwent treatment for 8 weeks.Outcomes including clinical efficacy,traditional Chinese medicine(TCM)syndrome scores,wound healing parameters,angiogenesis markers,micro-inflammatory status,and safety were compared between the two groups.Results:Ultimately,65 patients in the observation group and 65 in the control group completed the full course of treatment and were included in the efficacy analysis.After 8 weeks of treatment,the overall response rate was signifi-cantly higher in the observation group(93.85％)compared to the control group(81.54％)(P＜0.05).After 8 weeks of treatment,TCM syndrome scores(including scores for primary and secondary symptoms,and the total score)decreased compared with baseline in both groups,and the observation group had lower scores than the control group(P＜0.05).The wound area decreased significantly in both groups after treatment,with a more pronounced reduction in the observa-tion group(P＜0.05).The observation group also exhibited a shorter wound healing time and a higher wound healing rate compared to the control group(P＜0.05).Furthermore,levels of basic fibroblast growth factor(bFGF)and vascular endothelial growth factor(VEGF)increased,while serum endostatin(ES)decreased in both groups after treatment;these changes were more significant in the observation group(P＜0.05).Levels of interleukin-6(IL-6),interleukin-18(IL-18),and tumor necrosis factor-α(TNF-α)were lower post-treatment in both groups,with the observation group showing lower levels than the control group(P＜0.05).During the treatment period,vital signs remained stable in both groups,and no treatment-related abnormalities were observed in liver and kidney function,routine blood tests,or coagulation func-tion.No significant adverse reactions occurred,indicating a favorable safety profile.Conclusion:The combination of Shengji Yuhong ointment and PRP injection is effective and safe for DFU patients.It alleviates clinical symptoms,accelerates wound repair,promotes angiogenesis,and mitigates inflammatory responses.