AVAPS无创呼吸模式治疗危重症急性呼吸衰竭患者的有效性研究OA
Study on the Effectiveness of AVAPS Non-invasive Ventilation Mode in the Treatment of Critically Ill Patients with Acute Respiratory Failure
目的:探讨平均容量保证压力支持(AVAPS)无创呼吸模式治疗危重症急性呼吸衰竭患者的临床效果.方法:选取 2025 年 1-10 月上饶市人民医院重症医学科收治的 86 例接受无创通气治疗的危重症急性呼吸衰竭患者,采用随机数字表法将其分为两组,各 43 例.对照组采用常规无创通气[自主/定时(S/T)模式]治疗,观察组采用 AVAPS 无创呼吸模式治疗.比较两组通气前与通气 4、8、12、24、48、72 h 后的动脉血气指标[pH 值、PaCO2、PaO2/吸入氧浓度(FiO2)],通气前与通气 72 h后生命体征(收缩压、舒张压、心率)、通气 7 d 内呼吸力学指标[潮气量(VT)、每分钟静息通气量(VE)、呼吸频率(RR)],以及临床转归情况.结果:通气 48、72 h 后,观察组 pH 值显著高于对照组(P<0.05);通气 8、12、72 h 后,观察组 PaCO2 显著低于对照组(P<0.05);通气 24、48、72 h 后,观察组 PaO2/FiO2 显著高于对照组(P<0.05).通气 72 h 后,两组收缩压、舒张压、心率较通气前降低,且观察组低于对照组(P<0.05).通气 7 d 内,观察组 VT、VE 高于对照组,RR 低于对照组(P<0.05).观察组气管插管率、住院期间死亡率低于对照组,但差异无统计学意义(P>0.05);观察组住院时间短于对照组(P<0.05).结论:AVAPS 无创呼吸模式治疗危重症急性呼吸衰竭,可更快速、有效地改善患者动脉血气、呼吸力学指标及生命体征,缩短住院时间.
Objective:To investigate the clinical effect of average volume assured pressure support(AVAPS)non-invasive ventilation mode in critically ill patients with acute respiratory failure.Method:Eighty-six critically ill patients with acute respiratory failure who received non-invasive ventilation in the Department of Critical Care Medicine,Shangrao People's Hospital from January to October 2025 were selected and divided into two groups by random number table method,with 43 cases in each group.The control group received conventional non-invasive ventilation[autonomous/timed(S/T)mode],and the observation group received AVAPS non-invasive ventilation mode.Arterial blood gas indexes[pH value,PaCO2,PaO2/fraction of inspired oxygen(FiO2)]before ventilation and after 4,8,12,24,48 and 72 hours of ventilation,vital signs(systolic blood pressure,diastolic blood pressure,heart rate)before ventilation and after 72 hours of ventilation,respiratory mechanics parameters[tidal volume(VT),minute resting ventilation(VE),respiratory rate(RR)]within 7 days of ventilation,and clinical outcomes were compared between the two groups.Result:After 48 and 72 hours of ventilation,the pH value of the observation group were significantly higher than those of the control group(P<0.05).After 8,12 and 72 hours of ventilation,PaCO2 in the observation group were significantly lower than those in the control group(P<0.05).After 24,48,and 72 hours of ventilation,the PaO2/FiO2 in the observation group were significantly higher than those in the control group(P<0.05).After 72 hours of ventilation,the systolic blood pressure,diastolic blood pressure and heart rate in both groups were lower than those before ventilation,and those of the observation group were lower than those of the control group(P<0.05).Within 7 days of ventilation,VT and VE in the observation group were higher than those in the control group,and RR was lower than that in the control group(P<0.05).The tracheal intubation rate and the mortality rate during hospitalization in the observation group were lower than those in the control group,but the differences were not statistically significant(P>0.05).The hospitalization time of the observation group was shorter than that of the control group(P<0.05).Conclusion:AVAPS non-invasive ventilation mode can more rapidly and effectively improve arterial blood gas,respiratory mechanics indexes and vital signs,shorten hospital stay.
王飞;王敢;汪嘉伟;娄文水
上饶市人民医院重症医学科 江西 上饶 334000上饶市人民医院重症医学科 江西 上饶 334000上饶市人民医院重症医学科 江西 上饶 334000上饶市人民医院重症医学科 江西 上饶 334000
医药卫生
平均容量保证压力支持无创呼吸模式急性呼吸衰竭无创通气动脉血气呼吸力学临床转归
Average volume assured pressure support non-invasive ventilation modeAcute respiratory failureNon-invasive ventilationArterial blood gasRespiratory mechanicsClinical outcome
《中国医学创新》 2026 (25)
47-52,6
上饶市科技计划指导性项目(20242CZDX30)
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