常规三联疗法、双歧杆菌三联活菌联合参苓白术散治疗Hp阳性胃溃疡(脾虚湿阻证)的临床效果OA

Objective:To investigate the clinical efficacy of conventional triple therapy combined with Live Combined Bifidobacterium,Lactobacillus and Enterococcus and Shenling Baizhu Powder in the treatment of Hp-positive gastric ulcer(GU)(spleen deficiency with dampness obstruction syndrome).Method:A total of 84 patients with Hp-positive GU(spleen deficiency with dampness obstruction syndrome)who were admitted to Leping Hospital of Traditional Chinese Medicine from October 2024 to October 2025 were selected and divided into a treatment group and a control group using a random number table method,with 42 patients in each group.Both groups received conventional triple therapy.In addition,the control group was treated with Live Combined Bifidobacterium,Lactobacillus and Enterococcus,while the treatment group was treated with Live Combined Bifidobacterium,Lactobacillus and Enterococcus+Shenling Baizhu Powder.Treatment duration was 2 weeks for both groups.The gastric mucosal barrier function,traditional Chinese medicine(TCM)symptoms scores,Hp eradication rate,IL-6,TNF-α levels,adverse reactions,and clinical efficacy between the two groups were compared.Result:Four weeks after treatment,the treatment group exhibited lower pepsinogen(PG)Ⅰ,PGⅡ,TCM symptoms scores,and IL-6 and TNF-α compared to the control group,and higher Hp eradication rate compared to the control group(P<0.05).The incidence of adverse reactions in the treatment group was not statistically different from that in the control group(P>0.05).The total effective rate in the treatment group was higher than that of the control group(P<0.05).Conclusion:The combination of conventional triple therapy,Live Combined Bifidobacterium,Lactobacillus and Enterococcus and Shenling Baizhu Powder is safe and effective in treating Hp-positive GU(spleen deficiency with dampness obstruction syndrome).It can reduce the levels of serum IL-6 and TNF-α,improve the gastric mucosal barrier function,and increase the Hp eradication rate.