自拟心衰方联合沙库巴曲缬沙坦治疗非左心室射血分数减少心力衰竭(阳虚水泛证)的临床效果OA

Objective:To evaluate the efficacy and safety of self-made Xinshuai Formula combined with Sacubitril Valsartan in the treatment of non-left ventricular ejection fraction reduced heart failure(Yang deficiency and water overflow syndrome).Method:A total of 120 patients with non-left ventricular ejection fraction reduced heart failure(Yang deficiency and water overflow syndrome)who were treated at Yiwu Traditional Chinese Medicine Hospital from March 2024 to March 2025 were prospective selected.The patients were divided into a control group(n=60)and an observation group(n=60)using a random number table method.Both groups received conventional basic treatment.The control group was given Sacubitril Valsartan,while the observation group was treated with the self-made Xinshuai Formula in addition to the treatment of the control group.The treatment duration was 2 weeks for both groups.The traditional Chinese medicine(TCM)syndromes scores,serum N-terminal pro-brain natriuretic peptide(NT-proBNP),cardiac structure and function indicators[left atrial diameter(LAD),left ventricular end-diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),left atrial volume index(LAVI),ratio of early diastolic transmitral flow velocity to mitral annular early diastolic velocity(E/e')],6-minute walk test(6MWT),and Kansas City cardiomyopathy questionnaire total symptom score(KCCQ-TSS)of the two group were evaluated.The clinical total response rate,rehospitalization rate,and incidence of adverse events of the two group were compared.Result:The clinical total response rate of the observation group was higher than that of the control group,and the rehospitalization rate was lower than that of the control group(P<0.05).After 1 and 2 weeks of treatment,the scores of various TCM syndromes,NT-proBNP,LAVI,and E/e'in the observation group were lower than those in the control group,LAD was smaller than that in the control group,6MWT was longer than that in the control group,and KCCQ-TSS and LVEF were higher than those in the control group(P<0.05).The LVEDD of the observation group was smaller than that of the control group after 2 weeks of treatment(P<0.05).The comparison of the LVEDD after 1 week of treatment and the total incidence rates of adverse events between the two groups showed no statistically significant difference(P>0.05).Conclusion:The combination of self-made Xinshuai Formula and Sacubitril Valsartan can effectively improve the TCM syndromes,cardiac structure and function,exercise tolerance,and quality of life of patients with non-left ventricular ejection fraction reduced heart failure(Yang deficiency and water overflow syndrome),reduce the risk of rehospitalization,and has good safety.