清肺培本汤治疗重型颅脑损伤合并胃肠功能障碍的临床效果OA
Clinical Efficacy of Qingfei Peiben Decoction in the Treatment of Severe Traumatic Brain Injury Combined with Gastrointestinal Dysfunction
目的:探讨清肺培本汤治疗重型颅脑损伤(sTBI)合并胃肠功能障碍的临床效果,并观察其对患者意识状态、炎症反应及并发症的影响.方法:选取2024年1月—2025年12月长沙市中医医院收治的82例sTBI 合并胃肠功能障碍患者,按照随机数字表法分为观察组和对照组,每组 41 例.对照组予以西医常规综合治疗,观察组在对照组的治疗基础上联用清肺培本汤治疗.两组疗程均为 15 d.比较两组临床疗效、胃肠功能指标[腹内压(IAP)、胃肠功能衰竭(GIF)评分]、格拉斯哥昏迷量表(GCS)评分、炎症指标(WBC、CRP、IL-6)及并发症发生率.结果:治疗后,观察组的临床总有效率达 92.68%,显著高于对照组的75.61%(P<0.05).治疗7 d后,观察组IAP水平低于对照组(P<0.05);治疗5、15 d后,观察组 GIF 评分低于对照组(P<0.05);治疗 15 d 后,观察组 GCS 评分高于对照组(P<0.05);治疗 5、15 d 后,观察组血清 WBC、CRP、IL-6 水平均低于对照组(P<0.05);观察组并发症总发生率显著低于对照组(P<0.05).结论:清肺培本汤可有效促进 sTBI 合并胃肠功能障碍患者的胃肠功能恢复,改善意识状态,减轻机体炎症反应,降低并发症发生率,提升临床疗效.
Objective:To explore the clinical effect of Qingfei Peiben Decoction in the treatment of severe traumatic brain injury(sTBI)combined with gastrointestinal dysfunction,and to observe its influence on the patients'consciousness state,inflammatory response and complications.Method:A total of 82 patients with sTBI combined with gastrointestinal dysfunction who were admitted to Changsha Hospital of Traditional Chinese Medicine from January 2024 to December 2025 were selected and divided into the observation group and the control group by random number table method,with 41 cases in each group.The control group was given conventional comprehensive treatment by western medicine,while the observation group was treated with Qingfei Peiben Decoction on the basis of the control group.The treatment courses of both groups were 15 days.The clinical efficacy,gastrointestinal function indicators[intra-abdominal pressure(IAP),gastrointestinal failure(GIF)score],Glasgow coma scale(GCS)score,inflammatory indicators(WBC,CRP,IL-6),and incidence of complications between the two groups were compared.Result:After treatment,the total clinical effective rate of the observation group reached 92.68%,significantly higher than 75.61% of the control group(P<0.05).After 7 days of treatment,the IAP level in the observation group was lower than that in the control group(P<0.05).After 5 and 15 days of treatment,the GIF scores of the observation group were lower than those of the control group(P<0.05).After 15 days of treatment,the GCS score of the observation group was higher than that of the control group(P<0.05).After 5 and 15 days of treatment,the levels of serum WBC,CRP and IL-6 in the observation group were all lower than those in the control group(P<0.05).The total incidence of complications in the observation group was significantly lower than that in the control group(P<0.05).Conclusion:Qingfei Peiben Decoction can effectively promote the recovery of gastrointestinal function in patients with sTBI combined with gastrointestinal dysfunction,improve their state of consciousness,reduce the inflammatory response of the body,lower the incidence of complications,and enhance clinical efficacy.
曾玉;段继新;罗凯;李中丽
湖南中医药大学附属长沙市中医医院(长沙市第八医院)神经外科 湖南 长沙 410100||湖南中医药大学研究生院 湖南 长沙 410208湖南航天医院神经疾病医学部 湖南 长沙 410205湖南中医药大学附属长沙市中医医院(长沙市第八医院)神经外科 湖南 长沙 410100湖南中医药大学研究生院 湖南 长沙 410208
医药卫生
清肺培本汤重型颅脑损伤胃肠功能炎症指标
Qingfei Peiben DecoctionSevere traumatic brain injuryGastrointestinal functionInflammatory indicators
《中国医学创新》 2026 (25)
1-6,6
长沙市2024年度第二批指导性科技计划项目(kzd2402004)
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