凝胶伤口敷料在中厚皮片移植修复手部深Ⅱ度及Ⅲ度烧伤创面中的应用OA

Objective To investigate the effect of wound gel combined with split-thickness skin grafting on the repair of hand deep second-degree and third-degree burn wounds.Methods A retrospective analysis was conducted on the clinical data of 120 patients with second-and third-degree hand burns who underwent autologous split-thickness skin grafting in the hospital from March 2022 to March 2025.Based on the pre-operative dressings used,they were divided into a control group(n=63)and a study group(n=57).The study group was treated with wound gel,while the control group was treated with silver sulfadiazine cream treatment.The following parameters were compared between the two groups:wound healing status,angiogenesis-related indicators,inflammatory markers,pain intensity during dressing changes,wound scarring condition,and safety profiles.Results Patients in the study group demonstrated better outcomes than those in the control group,with a shorter skin graft bed preparation time,a shorter wound healing time,a lower wound bacterial positivity rate,and a higher skin graft survival rate(all P＜0.05).The levels of vascular endothelial growth factor(VEGF)and erythropoietin(EPO)in the study group were significantly higher than those in the control group(all P＜0.05).In contrast,the study group showed lower levels of intercellular adhesion molecule-1(ICAM-1),C-reactive protein(CRP),and procalcitonin(PCT),along with lower visual analog scale(VAS)scores for pain during postoperative dressing changes,lower postoperative scar hyperplasia rate,lower Vancouver Scar Scale(VSS)scores,lower pruritus scores,and a lower total incidence of complications compared with the control group(all P＜0.05).Conclusion The combination of wound gel and split-thickness skin grafting in patients with deep second-and third-degree hand burns may accelerate wound healing,improve skin graft survival,alleviate post-operative pain,and optimize wound scarring outcomes by promoting angiogenesis,mitigating inflammatory responses,and controlling bacterial infections,with a favorable safety profile.