"七情致病"的现代生物学机制研究进展OA

The theory of seven emotions triggering diseases is a core concept in traditional Chinese medicine(TCM)etiology,empha‑sizing that excessive emotional stimulation can lead to disorders in qi circulation and organ functions,which is highly consistent with modern psychosomatic medicine.Emotional disorders are closely related to acute and chronic stress injuries.This article systematically reviews the modern biological research progress on the theory of seven emotions causing diseases,summarizes the common pathways at the level of neuro-endocrine-immune(NEI)network dysregulation,and explores the unique patterns of different emotions in regulating the hypothalamic-pituitary-adrenal axis(HPA),autonomic nervous system,central brain regions,and immune inflammatory responses.It provides a partial scientific explanation for the theory of"five emotions damaging five organs"and offers new evidence for elucidating the biological essence of emotional disorders.Future research integrating multiple systems and employing advanced technolo‑gies will further promote the modernization and clinical translation of this theory,opening new avenues for precise prevention and treat‑ment of psychosomatic diseases.