抗菌功能柞蚕丝医用缝合线的制备及性能研究OA

To address the insufficient antibacterial performance of traditional medical silk sutures and the high risk of postoperative infections,this study utilized natural tussah silk as the raw material and processed it into medical sutures through a braiding technique.Tussah silk,owing to its favorable mechanical properties and natural origin,has mechanical performance between that of domestic silkworm silk and spider silk,making it a promising suture material.In this study,a composite antibacterial coating composed of varying concentrations of moxifloxacin(MXF),polyethylene glycol(PEG),and silk fibroin(SF)was introduced onto the surface of the braided tussah silk sutures,producing sutures with long-lasting antibacterial properties.In this coating system,MXF serves as the active antibacterial agent,PEG acts as a component to regulate drug dispersion and release,and SF provides a biocompatible film-forming matrix.The three components work synergistically to form a stable functional coating on the suture surface with sustained drug release capability. To systematically evaluate the performance of the prepared sutures,this study investigated the effects of MXF loading on suture surface morphology,diameter and weight,mechanical properties,drug release behavior,and antibacterial performance.The results demonstrated that the composite coating stably adhered to the surface of the tussah silk sutures without affecting their overall geometry or mass.The coated sutures maintained good structural uniformity and exhibited physicochemical characteristics suitable for surgical applications.With increasing MXF concentration,the drug release rate of the sutures increased significantly,with cumulative release exceeding 70%within 24 h,indicating favorable release characteristics of the coating system.Since wounds are more susceptible to contamination and inflammation in the early postoperative period,these sutures are advantageous for preventing bacterial infections at the early stage after surgery. Regarding mechanical properties,all coated samples maintained a breaking strength above 20 N,indicating that surface functionalization did not compromise the basic load-bearing capacity required for clinical suturing.Furthermore,all samples met the diameter specifications of YY 0167-2020 Non-absorbable Surgical Sutures,demonstrating that the coated sutures retained good dimensional stability and complied with medical suture standards.Antibacterial testing further indicated that increasing MXF concentration significantly enhanced antibacterial performance,showing that higher drug loading directly improves the antibacterial effect.Therefore,the MXF/PEG/SF composite coating strategy not only endows tussah silk sutures with effective antibacterial functionality but also preserves their essential mechanical and dimensional characteristics. In summary,this study validates the feasibility and application potential of tussah silk in functional medical sutures.By constructing a drug-loaded composite antibacterial coating on braided tussah silk sutures,a new type of suture material with antibacterial activity,adequate mechanical strength,dimensional compliance,and controlled drug release was developed.These findings provide valuable insights for the design,optimization,and innovation of advanced silk-based medical sutures and hold promise for their future clinical translation.