肿瘤临床试验受试者治疗期望在社会支持与应对疲惫间的中介作用OA

Objective To explore the mediating effect of treatment expectations on the relationship between social support and coping fatigue in cancer clinical trial subjects,thereby providing evidence for nursing interventions aimed at improving coping fatigue.Methods A total of 140 cancer clinical trial subjects treated at a Grade III-A cancer hospital in Tianjin from June to November 2025 were selected by convenience sampling.They were investigated using the General Information Questionnaire,the Social Support Rating Scale(SSRS),the Treatment Expectation Questionnaire(TEX-Q),and the Chinese version of the Brief Fatigue Inventory(BFI-C).Pearson correlation analysis was conducted to explore the correlations among social support,treatment expectations,and coping fatigue.Bootstrapping was conducted to analyze the mediating effect of treatment expectations on the relationship between social support and coping fatigue.Results Among these cancer clinical trial subjects,the total score of social support was(33.84±6.72)points,the treatment expectation score was(7.03±1.50)points,and the coping fatigue score was(5.03±2.15)points.Pearson correlation analysis showed that coping fatigue was negatively correlated with the total score and each dimension of social support(P<0.01 for all),and was negatively correlated with the total score and each dimension of treatment expectations(P<0.01 for all);social support was positively correlated with treatment expectations(P<0.01).Mediation analysis showed that treatment expectations partially mediated the relationship between social support and coping fatigue,with an indirect effect of-0.061(95％CI:-0.106 to-0.027),accounting for 48.4％of the total effect.Conclusion The social support,treatment expectations,and coping fatigue of cancer clinical trial subjects are all at a moderate level.Social support not only directly alleviates coping fatigue but also exerts an indirect effect on coping fatigue by enhancing treatment expectations.In clinical practice,targeted measures should be taken to enhance subjects'social support and help them develop realistic treatment expectations through health education and other strategies,thereby alleviating their coping fatigue.