温阳扶正类药物治疗溃疡性结肠炎研究进展OA

Ulcerative colitis(UC)is a chronic non-specific intestinal inflammatory disease characterized by protracted course and recur-rent occurrences.Spleen-kidney yang deficiency syndrome is a common type during the remission stage.Chinese medicinals with func-tions of warming yang and strengthening healthy qi exert unique advantages in UC therapy by warming and tonifying spleen-kidney yang and restoring the body's healthy qi.This paper systematically reviews modern pharmacological mechanisms underlying the intervention of such medicinals against UC.Existing studies demonstrate that Chinese medicinals with functions of warming yang and strengthening healthy qi can can modulate intestinal microbiota homeostasis,promote intestinal epithelial cell proliferation,balance immune cell popu-lations,suppress the release of inflammatory cytokines,and regulate energy metabolism,thereby alleviating intestinal inflammation,pre-serving the intestinal mucosal barrier and ameliorating UC-related symptoms.Nevertheless,current studies still face certain limitations including unidentified active constituents,ill-defined molecular targets,and insufficient mechanistic insights into intestinal microbiota modulation.Therefore,future research should adopt strategies such as activity guided isolation,multi omics technologies,gene editing and fecal microbiota transplantation to systematically elucidate the pharmacodynamic material basis and molecular networks of Chinese medicinals with functions of warming yang and strengthening healthy qi,so as to provide solid evidence for their precise clinical applica-tion and interpretation of scientific connotations.