中药复方防治放射性肺损伤研究进展OA

Radiation induced lung injury(RILI)is a common and severe complication following radiotherapy for thoracic malignancies.Its early manifestation is radiation pneumonitis,which may progress to irreversible radiation pulmonary fibrosis at the late stage,seriously impairing patients' quality of life and prognosis.At present,Western medicine mainly adopts glucocorticoids and symptomatic supportive therapies,which can hardly block the fibrotic process,and effective therapeutic approaches remain insufficient.Benefiting from the ad-vantages of multi-target and multi-pathway synergistic regulation,Chinese medicinal compound formulas have demonstrated unique po-tential in the prevention and treatment of RILI.This paper systematically reviews the research progress of Chinese medicinal compound formulas for RILI.Existing evidence indicates that such formulas can suppress inflammatory cascade responses,oxidative stress and epi-thelial-mesenchymal transition,and alleviate collagen deposition by modulating signaling pathways including TGF-β/Smad,NF-κB,Wnt/β-catenin,Nrf2/HO-1 and p38 MAPK.Consequently,they exert effects on regulating host immunity,improving pulmonary function and retarding fibrotic progression,which can improve patients' quality of life,with good safety.Nevertheless,current studies are confront-ed with several limitations,including inconsistent syndrome differentiation criteria,small sample sizes,fragmented mechanistic investiga-tions,ambiguous material basis of compounds,and undefined action targets.Therefore,in future research,unified diagnostic and efficacy evaluation criteria should be established,and multi-center,large-sample randomized controlled trials ought to be carried out.Individual-ized prevention treatment strategies should be explored.Multi-omics and organoid technologies should be integrated to clarify the phar-macodynamic material basis and molecular targets,so as to promote the evidence-based and international development of Chinese medic-inal compound formulas for RILI management.