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儿童中枢性性早熟的证治思路OA

Exploration of Syndrome-Treatment Thoughts on Central Precocious Puberty in Children

中文摘要英文摘要

中枢性性早熟的核心病机为少阳枢机不利,进而引发相火妄动、天癸早至,其病因与肾阴不足致枢机失养、情志失调致枢机郁滞、饮食不节致痰湿阻枢密切相关.治疗应以调畅少阳枢机为根本,具体治法有三:一是调畅枢机、滋阴清热以平相火,常以小柴胡汤为主方加减,或合用知柏地黄丸;二是疏利肝胆、条达气机以顺枢机,以柴胡为核心,加用香附、枳壳、郁金、黄芩、夏枯草、牡丹皮等;三是运脾化痰、宣通壅滞以利枢机,常以柴胡、黄芩配伍茯苓、白术、山药、半夏、陈皮、浙贝母等.通过上述治法,最终达到"枢机通利,相火平复,天癸有序"之目的.

The core pathogenesis of central precocious puberty(CPP)lies in the dysfunction of the Shaoyang pivot,which further leads to hyperactivity of ministerial fire and premature arrival of tiangui.Its etiology is closely associated with malnutrition of the pivot due to kidney-yin deficiency,pivot stagnation induced by emotional disturbance,and pivot obstruction caused by phlegm-dampness resulting from improper diet.Treatment should fundamentally focus on regulating and unblocking the Shaoyang pivot.First,regulate and unblock the pivot,nourish yin and clear heat to calm ministerial fire,with Modified Minor Bupleurum Decoction frequently adopted as the princi-pal formula,or combined with Anemarrhena and Phellodendron and Rehmannia Pill.Second,soothe and free the liver and gallbladder,regulate and smooth qi movement to harmonize the pivot.Chaihu(Bupleuri Radix)is used as the core herb,supplemented with Xiangfu(Cyperi Rhizoma),Zhiqiao(Aurantii Fructus),Yujin(Curcumae Radix),Huangqin(Scutellariae Radix),Xiakucao(Prunellae Spi-ca),Mudanpi(Moutan Cortex),etc.Third,activate the spleen to resolve phlegm and eliminate stagnation to facilitate pivot function.Chaihu(Bupleuri Radix)and Huangqin(Scutellariae Radix)are often combined with Fuling(Poria),Baizhu(Atractylodis Macro-cephalae Rhizoma),Shanyao(Dioscoreae Rhizoma),Banxia(Pinelliae Rhizoma),Chenpi(Citri Reticulatae Pericarpium),Zhebeimu(Fritillariae Thunbergii Bulbus)and so on.The above therapeutic methods ultimately achieve the goal of"unobstructed pivot,subdued ministerial fire,and orderly arrival of tiangui."

吴以诺;周云梦;叶进

南京中医药大学,南京中医药大学附属医院,江苏 南京 210029南京中医药大学,南京中医药大学附属医院,江苏 南京 210029南京中医药大学,南京中医药大学附属医院,江苏 南京 210029

医药卫生

中枢性性早熟"少阳为枢"理论小柴胡汤知柏地黄丸证治

central precocious puberty(CPP)theory of"Shaoyang as the pivot"Minor Bupleurum DecoctionAnemarrhena and Phel-lodendron and Rehmannia Pillsyndrome and treatment

《河南中医》 2026 (10)

1482-1486,5

江苏省妇幼健康研究会科研项目[苏妇幼研KYXM(2025)001]南京中医药大学自然科学基金项目(XZR2024008)

10.16367/j.issn.1003-5028.2026.10.0241

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