生物衰老加速与早期肾损伤风险的关联OA

Aim:To explore the association between biological aging acceleration and the risk of early kidney injury.Methods:Data of 5 261 subjects who underwent physical examination at the Health Management Center of the First Affilia-ted Hospital of Zhengzhou University from January to December 2024 were retrospectively collected.Biological age was esti-mated using the PhenoAge algorithm,and biological aging acceleration was calculated.Participants were divided into the ear-ly kidney injury group(urinary albumin-to-creatinine ratio＞3 mg/mmol)and the normal renal function group.Logistic re-gression analysis was used to analyze the association between the biological aging acceleration and early kidney injury.Re-sults:The biological aging acceleration was higher in the early kidney injury group than in the normal renal function group[(-1.20±4.50)vs(-3.60±3.90),P＜0.001].After adjusting for confounding factors including age,gender,educa-tional level,etc,the biological aging acceleration was positively associated with early kidney injury[OR(95％CI)=1.19(1.16-1.23)].Dose-response analysis showed that greater biological aging acceleration was associated with a higher risk of early kidney injury(P＜0.001).In different subgroups,the biological aging acceleration was positively associated with an elevated risk of early kidney injury(all OR＞1,all P＜0.001).Conclusion:There is a positive association between the bi-ological aging acceleration and early kidney injury.