冠心病患者植物性膳食模式与生物衰老速度的关联OA
Association between plant-based dietary patterns and biological aging rate in patients with coronary heart disease
目的:探讨冠心病患者植物性膳食模式与生物衰老速度的关联.方法:选取2023年9月至2024年9月河南某三甲医院心血管内科收治的537名冠心病患者为研究对象,开展横断面研究.收集人口学特征、生活习惯等资料,同时收集空腹静脉血,采用PhenoAge算法评估生物学年龄,生物衰老速度用生物学年龄与实际年龄回归所得残差表示.采用食物频率调查问卷收集食物摄入频次数据,计算总体植物性饮食指数(PDI)、健康植物性饮食指数(hPDI)和不健康植物性饮食指数(uPDI).应用多重线性回归模型分析不同饮食指数与冠心病患者生物衰老速度之间的关联.结果:多重线性回归分析表明,PDI与生物衰老速度负关联[β(95％CI)=-0.979(-1.728～-0.229),P=0.011].未发现hPDI、uPDI与生物衰老速度的显著关联.亚组分析显示,在≤60岁人群中,PDI、hP-DI 与生物衰老速度负关联[β(95％CI)=-1.606(-2.701～-0.511),-1.623(-2.731～-0.515),P＜0.05],而＞60岁人群未观察到该关联.结论:在冠心病患者中,更高的PDI可能与生物衰老速度延缓有关.
Aim:To explore the association between plant-based dietary patterns and biological aging rate in patients with coronary heart disease.Methods:A cross-sectional study was conducted among 537 patients with coronary heart disease admitted to the Department of Cardiology of a class A tertiary hospital in Henan Province from September 2023 to September 2024.Demographic characteristics and lifestyle information were collected.Fasting venous blood samples were obtained.Bio-logical age was assessed using the PhenoAge algorithm,and biological aging rate was represented by the residual derived from the regression of biological age on chronological age.Food frequency questionnaires were used to collect data on food intake frequency,and the overall plant-based diet index(PDI),healthy plant-based diet index(hPDI)and unhealthy plant-based diet index(uPDI)were calculated.Multiple linear regression models were applied to analyze the associations between differ-ent dietary indices and the biological aging rate in patients with coronary heart disease.Results:Multiple linear regression analysis indicated that PDI was negatively associated with the biological aging rate[β(95％CI)=-0.979(-1.728-0.229),P=0.011].No significant associations were found between hPDI or uPDI and the biological aging rate.Subgroup analysis showed that among individuals aged≤60 years,PDI and hPDI were negatively associated with the biological aging rate[β(95％CI)=-1.606(-2.701--0.511),-1.623(-2.731--0.515),P＜0.05],whereas no such associa-tions were observed among those aged＞60 years.Conclusion:A higher PDI may be associated with decelerated biological aging among patients with coronary heart disease.
陈洁;张斯羽;张景云;张晓晴;海沛;吕全军;薄亚聪
郑州大学公共卫生学院 郑州 450001郑州大学公共卫生学院 郑州 450001郑州大学公共卫生学院 郑州 450001郑州健康学院 郑州 450064郑州健康学院 郑州 450064郑州健康学院 郑州 450064||郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001郑州大学公共卫生学院营养与食品卫生学教研室 郑州 450001
医药卫生
衰老生物学年龄植物性膳食模式冠心病生物衰老速度
agingbiological ageplant-based dietary patternscoronary heart diseasebiological aging rate
《郑州大学学报（医学版）》 2026 (5)
8-12,5
国家自然科学基金项目(82504406)
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