人体衰老检测技术的研究进展OA
Research advances in human aging detection technologies
全球老龄化进程加速背景下,衰老检测对健康衰老评估和疾病干预具有重要意义.目前单一的衰老检测技术涵盖分子水平(组学技术、DNA甲基化等)、细胞水平(衰老相关β-半乳糖苷酶、外泌体等)、组织水平(皮肤成像、肌肉影像学等)及功能水平(步态分析、认知评估等).单一技术虽能精准检测特定指标,但存在个体差异显著、易受环境干扰等局限.本文综述了上述衰老检测技术的研究进展,剖析多模态整合策略在构建全面精准的衰老评估体系的前景,为衰老检测技术的临床转化提供理论支撑.
With the acceleration of the global aging process,aging detection technologies are of great significance for healthy aging assessment and disease intervention.Current single aging detection technologies cover the molecular level(omics technologies,DNA methylation,etc.),cellular level(senescence-associated β-galactosidase,exosomes,etc.),tissue level(skin imaging,muscle imaging,etc.)and functional level(gait analysis,cognitive assessment,etc.).Although a single technology can accurately detect specific indicators,it has limitations such as significant individual differences and suscepti-bility to environmental interference.This paper reviews the research progress of the above-mentioned single detection tech-nologies,analyzes the prospect of multimodal integration strategies in constructing a comprehensive and accurate aging as-sessment system,and provides theoretical support for the clinical transformation of aging detection technologies.
周志毫;卢俊峰;郑亚东;李立国
河南省医学科学院康复医学与康养研究所 郑州 451163河南省医学科学院康复医学与康养研究所 郑州 451163河南省医学科学院康复医学与康养研究所 郑州 451163河南省医学科学院康复医学与康养研究所 郑州 451163
医药卫生
衰老检测DNA甲基化外泌体多模态整合
aging detectionDNA methylationexosomesmultimodal integration
《郑州大学学报(医学版)》 2026 (5)
1-7,7
河南省重点研发与推广专项(科技攻关)基金资助项目(232102310481,212102311131)
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