基于数据挖掘的关思友教授治疗崩漏用药规律研究OA

Objective To systematically explore the prescription compatibility rules of Professor GUAN Siyou for metrorrhagia and metrostaxis based on clinical medical case data.Methods A retrospective analytical method was adopted.The medical records of Professor GUAN collected from 2008 to 2014 were retrieved and screened according to inclusion and exclusion criteria.Information of the four diagnostic methods(age,tongue coating,tongue proper,pulse condition)and prescription data(herb varieties,dosage,four natures,five flavors,channel tropism,medication frequency,etc.)were extracted to establish a database.Data entry was performed by two researchers independently using Excel followed by cross-checking for verification.Python 3.12.2 software was utilized for cluster analysis and association rule analysis.Results A total of 155 prescriptions involving 109 Chinese herbal medicines were included,with the total medication frequency reaching 2236.In terms of medicinal properties,warm and neutral natures predominated;the predominant medicinal tastes were sweet and bitter,and the herbs mainly attribute to the liver,spleen and kidney meridians.K-Means cluster analysis categorized all herbs into four clusters as follows:cluster 1 consisted of Astragali Radix,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma,Amomi Fructus and Codonopsis Radix,cluster 2 contained Rehmanniae Radix Preparata,Corni Fructus,Eucommiae Cortex,Dipsaci Radix,Dioscoreae Rhizoma,Rubiae Radix et Rhizoma,Bletillae Rhizoma and Taxilli Herba,cluster 3 was Glycyrrhizae Radix et Rhizoma alone,cluster 4 included Agrimoniae Herba,Mori Folium,Asini Corii Colla,Paeoniae Radix Alba,Notoginseng Radix et Rhizoma and Imperatae Rhizoma.Association rule analysis indicated that the most frequently used herbs were Astragali Radix,Angelicae Sinensis Radix,Atractylodis Macrocephalae Rhizoma and Mori Folium.The high-frequency herb combinations were Agrimoniae Herba-Angelicae Sinensis Radix-Mori Folium and Agrimoniae Herba-Mori Folium-Atractylodis Macrocephalae Rhizoma.Conclusion Professor GUAN adopted a prescription formulation philosophy combining dynamic and static therapies for the treatment of metrorrhagia and metrostaxis.The herb pair Mori Folium(mulberry leaf)and Agrimoniae Herba(agrimony)served as the core medicinal combination in prescriptions,which can provide evidence-based references for the clinical management of metrorrhagia and metrostaxis.