地黄启膈饮联合小剂量化疗治疗晚期老年食管和食管胃结合部癌临床研究OA

Objective To explore the effects of Dihuang Qige drink combined with low-dose chemotherapy on clinical efficacy,quality of life and adverse reactions in elderly patients with advanced esophageal cancer and esophagogastric junction cancer.Methods A total of 90 inpatients with advanced esophageal cancer and esophagogastric junction cancer treated in Department of Oncology of Changzhi Hospital of Traditional Chinese Medicine from January 2023 to December 2024 were enrolled and randomly divided into an experimental group(treated with Dihuang Qige drink combined with low-dose chemotherapy)and a control group(treated with standard-dose chemotherapy),with 45 patients in each group.After 2 cycles of treatment,the two groups were evaluated from five dimensions as follows:short-term efficacy(tumor lesion remission),long-term survival(progression-free survival),clinical symptoms(traditional Chinese medicine(TCM)syndrome score),functional status(quality of life)and safety(adverse reactions).Results There was no significant difference between the two groups in objective response rate(ORR:35.56%vs 33.33%)and disease control rate(DCR:80.00%vs 75.56%).However,the experimental group was significantly superior to the control group in improving TCM syndromes(such as dysphagia and lassitude)and enhancing quality of life(KPS score)(P<0.05).More importantly,the incidence of grade Ⅱ‒ Ⅳ myelosuppression in the experimental group was markedly lower than the control group(P<0.05).Conclusion Dihuang Qige drink combined with low-dose chemotherapy could effectively control tumor lesions,prolong progression-free survival,ameliorate TCM clinical symptoms,improve the quality of life,and significantly reduce the incidence of severe myelosuppression in elderly patients with advanced esophageal cancer and esophagogastric junction cancer.