银星养脑片治疗脑小血管病脑白质病变轻度认知功能障碍的临床研究OA
Clinical Study of Yinxing Yangnao Tablets in the Treatment of Mild Cognitive Impairment with White Matter Lesions Due to Cerebral Small Vessel Disease
目的 探讨银星养脑片对脑小血管病脑白质病变所致轻度认知功能障碍的临床疗效.方法 选取2024年6月—2025年9月浏阳市中医医院收治的脑小血管病脑白质病变轻度认知功能障碍患者60例,随机分为对照组与观察组,每组30例,所有患者均接受常规西医治疗,观察组在此基础上加用银星养脑片,2组疗程均为3个月.分别评估治疗前后患者蒙特利尔认知评估量表(MoCA)评分,中医证候积分,血清白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及超敏C反应蛋白(hs-CRP)水平变化,统计分析疗效差异.结果 治疗后,观察组总有效率高于对照组(P<0.01),观察组中医证候积分低于对照组(P<0.01),观察组MoCA评分高于对照组,观察组血清IL-6、TNF-α及hs-CRP水平降低程度大于对照组,差异有统计学意义(P<0.05).结论 银星养脑片可改善脑小血管病轻度认知功能障碍患者的认知功能,其作用机制可能与拮抗中枢神经炎症反应相关.
Objective To evaluate the clinical efficacy of Yinxing Yangnao tablets in the treatment of mild cognitive impairment with white matter lesions due to cerebral small vessel disease.Methods Sixty patients diagnosed with mild cognitive impairment with white matter lesions due to cerebral small vessel disease admitted to Liuyang Hospital of Traditional Chinese Medicine from June 2024 to September 2025 were enrolled and randomly divided into a control group and an observation group,with 30 cases in each group.All patients received conventional Western medicine treatment.On this basis,the observation group was additionally treated with Yinxing Yangnao tablets.The treatment course for both groups lasted 3 months.The Montreal cognitive assessment(MoCA)score,traditional Chinese medicine(TCM)syndrome score,serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and high-sensitivity C reactive protein(hs-CRP)of patients were evaluated before and after treatment.The differences in clinical efficacy between the two groups were statistically analyzed.Results After treatment,the total effective rate of the observation group was significantly higher than that of the control group(P<0.01).The decrease in TCM syndrome scores in the observation group was more remarkable than that in the control group(P<0.01).Meanwhile,the observation group presented a greater increase in MoCA scores and a more significant reduction in serum levels of IL-6,TNF-α and hs-CRP compared with the control group,and all the differences were statistically significant(P<0.05).Conclusion Yinxing Yangnao tablets could improve cognitive function in patients with mild cognitive impairment due to cerebral small vessel disease,and its mechanism of action might be related to antagonizing central neuroinflammatory responses.
熊鹰;邹开来;雷伊琳;赵洪江;黄志
浏阳市中医医院脑病医学中心三区,长沙 浏阳 410300浏阳市中医医院脑病医学中心三区,长沙 浏阳 410300浏阳市中医医院脑病医学中心三区,长沙 浏阳 410300浏阳市中医医院脑病医学中心三区,长沙 浏阳 410300浏阳市中医医院脑病医学中心三区,长沙 浏阳 410300
医药卫生
轻度认知功能障碍银星养脑片脑小血管病脑白质病变肾虚血瘀证
mild cognitive impairmentYinxing Yangnao tabletscerebral small vessel diseasecerebral white matter lesionskidney deficiency and blood stasis syndrome
《光明中医》 2026 (12)
1-5,5
湖南省中医药科研计划项目(No.D2024004)
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