能谱CT多参数成像在肺癌分化程度评估中的初步研究OA
Preliminary Study of Spectral CT Multi-parameter Imaging in Evaluating the Degree of Differentiation of Lung Cancer
目的:通过能谱CT多参数成像技术对肺部肿瘤患者进行检查,分析其在肺癌术前评估中的应用价值.方法:回顾性收集2023年1月至2023年6月期间在医院收治的40例肺部有实质病变的患者为研究对象,经手术病理检查诊断肺部病变的良恶性.所有患者术前均进行能谱CT多参数成像扫描检查,以手术病理学检查结果为金标准,比较良恶性病变参数差异,探讨能谱CT多参数成像技术在肺癌术前评估中的应用价值.结果:手术的病理结果显示,40例肺部病变患者中,恶性病变20例,良性病变20例.动脉期与静脉期良恶性肿瘤在不同keV对应的CT值比较显示,差异均具有统计学意义(P＜0.05);动脉期及静脉期良恶性肿瘤的碘值和能谱曲线斜率比较显示,差异均有统计学意义(P＜0.05),而动脉期及静脉期良恶性肿瘤的水浓度差异无统计学意义(P＞0.05).在动脉期及静脉期中,20例恶性病变按高、中、低分化肺癌分别为5例、10例、5例,三组的碘浓度、标准化碘浓度以及能谱曲线斜率随着分化程度的降低而增大,其中,碘浓度、标准化碘浓度以及能谱曲线斜率在动、静脉双期进行高-中、高-低、中-低组间两两比较时,差异均具有统计学意义(P＜0.05).能谱CT多参数(碘浓度、标准化碘浓度、能谱曲线斜率)在不同分化程度肺癌中存在显著差异(P＜0.05).结论:本研究显示,能谱CT多参数成像在评估肺癌分化程度方面具有一定潜力,可为临床治疗方案选择提供参考,其价值需大样本多中心研究进一步验证.
Objective:To analyze the application value of spectral CT multi-parameter imaging technology in the preoperative assessment of lung cancer by examining patients with pulmonary tumors.Methods:A retrospective collection of 40 patients with pulmonary parenchymal lesions admitted to the hospital between January 2023 and June 2023 was conducted.The benign or malignant nature of the pulmonary lesions was confirmed by surgical pathology.All patients underwent preoperative spectral CT multi-parameter imaging scans.Using surgical pathology results as the gold standard,the differences in parameters between benign and malignant lesions were compared to explore the application value of spectral CT multi-parameter imaging technology in the preoperative assessment of lung cancer.Results:Surgical pathology results showed that among the 40 patients with pulmonary lesions,20 had malignant lesions and 20 had benign lesions.During both the arterial and venous phases,the CT values corresponding to different keV levels showed statistically significant differences between benign and malignant tumors(P＜0.05).In both the arterial and venous phases,statistically significant differences were observed between benign and malignant tumors in iodine concentration and the slope of the spectral curve(P＜0.05),while the difference in water concentration was not statistically significant(P＞0.05).Among the 20 malignant lesions in both phases,classified as well-differentiated(5 cases),moderately-differentiated(10 cases),and poorly-differentiated(5 cases),the iodine concentration,normalized iodine concentration,and slope of the spectral curve increased as the degree of differentiation decreased.Pairwise comparisons(well vs.moderate,well vs.poor,moderate vs.poor)of iodine concentration,normalized iodine concentration,and slope of the spectral curve during both the arterial and venous phases all showed statistically significant differences(P＜0.05).Spectral CT multi-parameters(iodine concentration,normalized iodine concentration,slope of the spectral curve)exhibited significant differences among lung cancers with varying differentiation degrees(P＜0.05).Conclusion:This study shows that spectral CT multi-parameter imaging has a certain potential in evaluating the degree of differentiation of lung cancer,and provides a reference for the selection of clinical treatment options.Its value needs to be further verified by large sample multi center study.
余文庆;陈琳;张国晋
德阳市人民医院,四川 618000德阳市人民医院,四川 618000四川省人民医院,四川 610072
医药卫生
能谱CT多参数成像肺癌分化程度评估价值
spectral CT multi-parameter imaginglung cancerdifferentiation degreeapplication value
《影像科学与光化学》 2026 (6)
47-55,71,10
2023年四川省医学(青年创新)科研课题(S23086).
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