超声造影参数对非小细胞肺癌患者预后评估价值分析OA
Analysis of the Prognostic Value of Contrast-enhanced Ultrasound Parameters in Non-small Cell Lung Cancer Patients
目的:分析超声造影(contrast-enhanced ultrasound,CEUS)参数对非小细胞肺癌(non-small cell lung cancer,NSCLC)患者预后评估价值.方法:本研究为一项回顾性对照研究,便利抽样本院2020年1月至2022年1月就诊的150例NSCLC患者,根据所有患者入院后3年随访的生存状态,将其分为死亡组(n=78)和生存组(n=72),比较两组CEUS参数[造影剂到达时间(arrival time,AT)、峰值强度(peak intensity,PI)、达峰时间(time to peak,TTP)],Logistic 回归分析NSCLC 患者预后不良的影响因素,受试者工作特征曲线(ROC)分析CEUS参数对NSCLC患者预后不良的预测效能.结果:死亡组PI比生存组更高,差异有统计学意义(P＜0.05),死亡组TTP、AT均比生存组更低,差异有统计学意义(P＜0.05).PI、分化程度、临床分期是NSCLC患者预后不良的危险因素,TTP、AT是保护因素(P＜0.05).ROC曲线分析显示,PI最佳截断值取22.97 dB,TTP最佳截断值取18.04 s,AT最佳截断值取4.61 s时,PI、TTP、AT以及三项联合检测预测NSCLC患者预后不良的曲线下面积(AUC)分别为0.642、0.692、0.717、0.871,灵敏度分别为70.67％、73.52％、76.88％、92.76％,特异度分别为 82.38％、80.24％、81.20％、82.46％,PI、TTP、AT 三项联合检测的曲线下面积(area undercurve,AUC)高于单项检测,差异有统计学意义(Z/P值均＜0.05).结论:CEUS参数PI、TTP、AT联合检测可提高对NSCLC患者预后的预测效能,为NSCLC患者预后评估提供重要参考.
Objective:To analyze the prognostic evaluation value of contrast-enhanced ultrasound(CEUS)parameters for patients with non-small cell lung cancer(NSCLC).Methods:This study was a retrospective cohort study.A total of 150 NSCLC patients who visited our hospital from January 2020 to January 2022 were conveniently sampled.According to the survival status of all patients during the 3-year follow-up after admission,they were divided into the death group(n=78)and the survival group(n=72).The CEUS parameters[contrast agent arrival time(AT),peak intensity(PI),time to peak(TTP)]of the two groups were compared,and logistic regression was used to analyze the influencing factors of poor prognosis in NSCLC patients.The receiver operating characteristic curve(ROC)was used to analyze the predictive efficacy of CEUS parameters for poor prognosis in NSCLC patients.Results:The PI in the death group was higher than that in the survival group,and the difference was statistically significant(P＜0.05).The TTP and AT in the death group were both lower than those in the survival group,and the difference was statistically significant(P＜0.05).PI,differentiation degree and clinical stage are the risk factors for the poor prognosis of NSCLC patients,while TTP and AT are the protective factors(P＜0.05).The ROC curve shows that when the best cut-off value of PI is 22.97 dB,the best cut-off value of TTP is 18.04 s,and the best cut-off value of AT is 4.61 s,the area under the curve(AUC)of PI,TTP,AT and the three-item combined test for predicting poor prognosis of NSCLC patients are 0.642,0.692,0.717 and 0.871,respectively.The corresponding sensitivities are 70.67％,73.52％,76.88％and 92.76％,and the specificities are 82.38％,80.24％,81.20％and 82.46％.The AUC of combined detection of PI,TTP and AT is higher than that of each single-item detection,and the differences are statistically significant(all Z/P＜0.05).Conclusion:The combined detection of CEUS parameters PI,TTP and AT can improve the predictive efficacy for the prognosis of NSCLC patients and provide an important reference for the prognosis assessment of NSCLC patients.
何伟;曾健;姚浑鸿
自贡市第四人民医院超声医学科,四川 643000自贡市第四人民医院超声医学科,四川 643000自贡市第四人民医院超声医学科,四川 643000
医药卫生
超声造影非小细胞肺癌预后影响因素
contrast enhanced ultrasoundnon small cell lung cancerprognosisinfluence factors
《影像科学与光化学》 2026 (6)
33-39,7
四川省科技计划项目(2024SAT06).
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