纳米材料在深度血浆蛋白质组学中的应用进展OA

Plasma proteomics is an important technical tool for systematically characterizing physiological and pathological changes in the body,and it has demonstrated significant practical value in areas such as early disease diagnosis and pathological research.However,due to the complex composition of plasma proteins and the extremely wide dynamic range of protein abundance,the depth of plasma proteomics identification based on mass spectrometry technology is significantly limited.Currently,pretreatment strategies using nanomaterials to enrich low-abundance proteins in plasma have significantly enhanced the depth of identification in plasma proteomics,demonstrating considerable value for both clinical and research applications.This article provided a review of the mechanisms of action,typical material systems,and applications of nanomaterial-based enrichment of low-abundance proteins in plasma proteomics.It further explored the challenges facing this enrichment method and future directions for its development,offering guidance for establishing a highly efficient and accurate platform for in-depth plasma proteomics analysis and advancing its applications in elucidating disease mechanisms,discovering biomarkers,and advancing precision medicine.