基于ASAP-MS技术快速筛查非法添加及管制类药物OA

To achieve rapid screening and accurate identification of illegal additions and controlled drugs in multi-scenario applications,a rapid detection method based on atmospheric solids analysis-probe single-quadrupole mass spectrometry(ASAP-MS)was developed in this study.Focusing on an-tibiotics,glucocorticoids,anesthetics,antifungal agents,psychotropic substances,and novel psy-choactive substances,this study optimized the cone voltage parameters to acquire characteristic mass spectral information for each target compound under various voltage conditions,establishing an ASAP-MS rapid-detection database covering 111 target compounds.Library matching between the sample mass spectra and the in-house database was performed using LiveID software,and the screen-ing results were further verified using high-resolution mass spectrometry.Application of this method successfully identified target compounds such as lidocaine and diazepam in real samples,including disinfectant products and samples seized by law enforcement.This method requires facile sample pre-treatment,offers high analytical efficiency,and allows flexible database expansion.This enables the rapid screening of large sample volumes and meets the detection requirements of public safety fields,such as market regulation,customs inspection,and drug control enforcement,demonstrat-ing its good application value and broad potential for promotion.