具有级联纳米酶活性的三模态协同纳米复合材料:面向潜在的近红外响应切换成像与治疗OA

Herein,we designed and synthesized a multifunctional nanocomposite(UCNPs@FMn/ICG,denoted as UMI)that integrates upconversion luminescence imaging with trimodal synergistic therapy.This nanocomposite en-ables switching between upconversion luminescence imaging and a combined photodynamic(PDT),photothermal(PTT),and chemodynamic therapy(CDT)response simply by altering the excitation wavelength.Under 980 nm ir-radiation,UMI exhibited intense upconversion emission,demonstrating its potential for applications in near-infrared(NIR)-mediated optical imaging.When excited at 808 nm,UMI generated reactive oxygen species for PDT and pro-duced substantial heat for PTT,highlighting highly efficient dual photodynamic and photothermal functions.The PDT performance of UMI was evaluated by the photocatalytic degradation experiment of 1,3-diphenylisobenzofuran(DPBF).At a concentration of 400 μg·mL-1,UMI rapidly degraded 83.9％of DPBF within 30 s under 808 nm irra-diation(91.0 mW·cm-2).Simultaneously,it reached a temperature of 43.1℃ within 10 min under 560 mW·cm-2 irra-diation,achieving a photothermal conversion efficiency of around 43.3％.Thus,by synergizing pH-activated enzymatic catalysis and NIR-triggered phototherapeutic effects,UMI emerges as a versatile theranostic nanocomposite,paving the way for precise and efficient multimodal treatment guided by upconversion luminescence imaging.