从"脾虚浊毒"探析冠心病合并脂肪肝病机演变及诊疗思路OA

Coronary atherosclerotic heart disease(CHD)and metabolism-associated fatty liver disease(MAFLD)are core comorbidities of metabolic syndrome,showing significant interactions in pathological mechanisms and clinical outcomes,while their comorbidity rate shows a significant upward trend.Traditional Chinese medicine(TCM),based on the holistic concept and the principles of treatment based on syndrome differentiation,demonstrates advantages in multi-target,multi-level systemic regulation.Based on the theoretical framework of"spleen deficiency with turbid toxin,"this study systematically elucidates that the pathogenesis of CHD-MAFLD comorbidity is rooted in spleen deficiency and phlegm-turbidity,and turbid phlegm stagnates,gradully transforms into turbid toxin over time,and eventually forms a complex pathogenesis network.Sequential treatment protocol of"strengthening the spleen and removing turbidity-detoxifying and dredging collaterals-supporting healthy qi and preventing deterioration"has been proposed,which enables the recovery of the spleen and stomach,elimination of turbid pathogens,and restoration of healthy qi,allowing the body to reach a state of balance between yin and yang,providing new theoretical paradigms and intervention strategies for clinical practice.