125例胃癌前病变患者的中医证型分布规律与相关临床特点的回顾性研究OA

Objective:To investigate the distribution patterns of traditional Chinese medicine(TCM)syndrome types in patients with gastric precancerous lesions and their associations with clinical data,including gastroscopic mucosal changes,pathological diagnosis,Helicobacter pylori(Hp)infection,CEA,and carbohydrate antigen 19-9(CA19-9),so as to provide an evidence-based theoretical basis and new insights for TCM management of gastric precancerous lesions.Methods:The clinical data of 125 patients with gastric precancerous lesions confirmed by pathology were collected through a retrospective study using unified diagnostic criteria.A database was established for frequency statistics of general count data,and IBM SPSS 23.0 software was used for statistical analysis.Results:A total of 125 patients were included,among whom 77 were male(61.6%)and 48 were female(38.4%),with a gender ratio of 1.60:1.The patients ranged in age from 36 to 85 years,with a mean age of 62.00±9.54 years.The age distribution showed a bimodal pattern,with the 40-59 age group accounting for 33.6%and the 60-79 age group for 63.2%.The distribution of TCM syndrome types differed significantly;in descending order of composition ratio,they were:liver-stomach disharmony syndrome,spleen-stomach damp-heat syndrome,spleen-stomach deficiency syndrome,stomach collateral stasis syndrome,and stomach yin deficiency syndrome.The distributions of Hp infection,dysplasia,and mucosal thinning differed significantly among TCM syndrome types(P<0.05).Conclusion:Hp infection,pathological changes,and gastroscopic mucosal changes in gastric precancerous lesions are associated with the distribution of TCM syndrome types.Integrating the strengths of traditional medicine theory with modern medical diagnostic and treatment techniques can enrich the basis for clinical diagnosis and treatment.