补气活血方不同剂量颗粒剂对气虚痰瘀型缺血性脑卒中患者肢体功能障碍的影响OA

Objective:To clarify the effect of different doses of Buqi Huoxue dispensing granules on limb dysfunction in patients with ischemic stroke of qi deficiency and phlegm-stasis pattern.Methods:Sixty eligible patients with ischemic stroke of qi deficiency and phlegm-stasis pattern were randomly divided into a decoction pieces group,an equal-dose granules group,and a half-dose granules group,with 20 cases in each group.The three groups were treated with Buqi Huoxue decoction pieces,equal-dose dispensing granules,and half-dose dispensing granules,respectively,one dose daily for 2 weeks.The Modified Rankin Scale(mRS),National Institutes of Health Stroke Scale(NIHSS),Barthel Index(BI),and Fugl-Meyer Assessment(FMA)were used to evaluate efficacy before treatment and after 1 and 2 weeks of treatment.Results:After 2 weeks of treatment,the NIHSS and mRS scores of the three groups were lower than those before treatment(P<0.05),and the BI and FMA scores were higher than those before treatment(P<0.05).Inter-group comparison showed that at 1 week of treatment,the mRS score of the equal-dose granules group was higher than that of the half-dose granules group(P<0.05),with no significant differences in the other indicators(P>0.05).At 2 weeks of treatment,there were no significant differences in any scale scores between the decoction pieces group and the equal-dose granules group(P>0.05),but the improvements inNIHSS,BI,and FMA scores in these two groups were significantly better than those in the half-dose granules group(P<0.05).No obvious adverse reactions occurred in any of the three groups.Conclusion:Buqi Huoxue equal-dose dispensing granules are as effective as traditional decoction pieces in treating ischemic stroke of qi deficiency and phlegm-stasis pattern,and are significantly superior to the half-dose granules;they can therefore serve as a convenient clinical alternative.Although the half-dose granules provide certain clinical benefits,their long-term efficacy is inferior to that of the full dose,and this should be carefully weighed in clinical application.