耐碳青霉烯类肠杆菌目细菌血流感染的中西医临床特征及危险因素分析OA

Objective:To analyze the clinical characteristics in both traditional Chinese and western medicine and risk factors of carbapenem-resistant enterobacterales(CRE)bloodstream infections in the intensive care unit(ICU)of a traditional Chinese medicine(TCM)hospital.Methods:Clinical data of patients with enterobacterales bloodstream infections admitted to the Department of Critical Care Medicine,Beijing Hospital of Traditional Chi-nese Medicine,Capital Medical University from July 2016 to January 2025 were retrospectively analyzed.Patients were divided into the CRE group and carbapenem-susceptible enterobacterales(CSE)group according to drug re-sistance profiles.Clinical characteristics were compared between the two groups,and univariate analysis as well as multivariate Logistic regression were performed to identify relevant risk factors for CRE infection.Results:Univar-iate analysis indicated that SOFA score,onset time after ICU admission and urine volume were associated with CRE infection(P<0.05).Multivariate Logistic regression analysis revealed that altered mental status was a risk factor for CRE bloodstream infections(P<0.05).Conclusion:Clinicians should closely monitor the mental status of ICU patients and shorten the length of ICU stay to reduce the incidence of CRE bloodstream infections.