颊针疗法联合美洛昔康片治疗腰椎间盘突出症(血瘀证)急性期临床观察OA
Clinical Observation on Cheek Acupuncture Therapy Combined with Meloxicam Tablets in Treating Acute Stage of Lumbar Disc Herniation(Syndrome of Blood Stasis)
目的 观察颊针疗法联合美洛昔康片治疗腰椎间盘突出症(血瘀证)急性期的临床疗效.方法 将152例腰椎间盘突出症(血瘀证)急性期患者随机分为对照组与观察组,各76例.对照组口服美洛昔康片,观察组在对照组基础上联合颊针疗法,疗程均为2周.比较两组临床疗效,治疗前后中医证候积分、疼痛视觉模拟评分(VAS)、简化McGill疼痛问卷(SF-MPQ)评分、Oswestry功能障碍指数(ODI)、日本骨科学会评估治疗评分(JOA),并检测血清降钙素基因相关肽(CGRP)、P物质(SP)、内皮素-1(ET-1)及白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、前列腺素E2(PGE2)水平,统计不良反应发生率.结果 观察组临床总有效率高于对照组(P<0.05).治疗后观察组中医证候积分、VAS评分、SF-MPQ评分、ODI评分均低于对照组(P<0.05),JOA评分高于对照组(P<0.05).观察组血清SP、ET-1、IL-1β、IL-6、TNF-α、PGE2水平均低于对照组(P<0.05),CGRP水平高于对照组(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论 颊针疗法联合美洛昔康片能有效缓解腰椎间盘突出症(血瘀证)急性期患者疼痛,改善腰椎功能,其作用机制可能与调节疼痛介质及炎症因子表达有关,临床疗效显著,安全性良好.
Objective:To observe the clinical efficacy of cheek acupuncture therapy combined with meloxicam tablets in treating acute stage of lumbar disc herniation(syndrome of blood stasis).Methods:A total of 152 pa-tients with acute stage of lumbar disc herniation(syndrome of blood stasis)were randomly divided into the control group and observation group,with 76 cases in each group.The control group was treated with oral meloxicam tab-lets,and the observation group was combined with cheek acupuncture therapy on the basis of the control group,with a course of 2 weeks.The clinical efficacy of the two groups was compared,including TCM syndrome score,Vi-sual Analogue Scale(VAS)score,Short-Form McGill Pain Questionnaire(SF-MPQ)score,Oswestry Disability In-dex(ODI),Japanese Orthopaedic Association(JOA)score before and after treatment.The serum levels of calcito-nin gene-related peptide(CGRP),substance P(SP),endothelin-1(ET-1),interleukin-1β(IL-1β),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and prostaglandin E2(PGE2)were detected,and the incidence of ad-verse reactions was counted.Results:The total clinical effective rate of the observation group was higher than that of the control group(P<0.05).After treatment,the TCM syndrome score,VAS score,SF-MPQ score and ODI score in the observation group were lower than those in the control group(P<0.05),while the JOA score was high-er than that in the control group(P<0.05).The serum levels of SP,ET-1,IL-1β,IL-6,TNF-α and PGE2 in the observation group were lower than those in the control group(P<0.05),while the CGRP level was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Cheek acupuncture therapy combined with meloxicam can effectively re-lieve pain in patients with acute stage of lumbar disc herniation(syndrome of blood stasis),and improve lumbar function.Its mechanism may be related to regulating the expression of pain mediators and inflammatory factors,with remarkable clinical efficacy and good safety.
张爽;姚娟;陈烨;唐在荣
扬州大学医学部,江苏 扬州 225000||江苏省南通市海门区人民医院,江苏 南通 226100江苏省高邮市中医医院,江苏 高邮 225600江苏省南通市海门区人民医院,江苏 南通 226100江苏省高邮市中医医院,江苏 高邮 225600
医药卫生
腰椎间盘突出症颊针疗法美洛昔康血瘀证疼痛介质炎症因子腰椎功能
Lumbar disc herniationCheek acupuncture therapyMeloxicamSyndrome of blood stasisPain me-diatorsInflammatory factorsLumbar function
《中国中医急症》 2026 (9)
1062-1065,4
扬州市卫生健康委员会科研项目(2023-2-29)
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