当归拈痛汤配合中药外敷对急性痛风性关节炎患者疼痛程度及外周炎症因子水平的影响OA

Objective:To observe the effects of Danggui Niantong Decoction combined with external TCM appli-cation on pain degree and peripheral inflammatory factors in patients with acute gouty arthritis(AGA)of syndrome of dampness-heat accumulation.Methods:A total of 106 AGA patients were divided into the control group and observation group(53 cases per group)by random number table method.The control group received conventional western medicine treatment,while the observation group was additionally given oral Danggui Niantong Decoction plus external application of No.1 Xingshang for one week.TCM syndrome scores,Visual Analogue Scale(VAS)score,serum levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and eryth-rocyte sedimentation rate(ESR)before and after treatment were compared.Clinical efficacy and adverse reactions were counted.Results:After treatment,the scores of TCM symptoms and VAS score in the observation group were lower than those in the control group(P<0.05).Serum IL-6,TNF-α,CRP and ESR levels of the observation group were significantly decreased compared with the control group(P<0.05).The total effective rate of the obser-vation group was 96.23%,which was higher than 79.25%of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:For AGA pa-tients with dampness-heat accumulation syndrome,combined therapy of Danggui Niantong Decoction and external TCM medication can obviously relieve joint pain and swelling,reduce peripheral inflammatory factors and improve clinical efficacy without increasing the risk of adverse reactions.