重症肺炎中医证候与证素分布特征的文献计量与数据挖掘研究OA

Objective:To explore the distribution rules of traditional Chinese medicine(TCM)syndromes and syndrome elements of severe pneumonia via literature analysis,and to provide practical reference for standardized TCM syndrome differentiation and clinical diagnosis and treatment of severe pneumonia.Methods:Clinical re-search literatures regarding TCM syndromes of severe pneumonia were retrieved from CNKI,WanFang Database and VIP Database.The syndromes,syndrome elements,symptoms and signs recorded in literatures were systemati-cally sorted out,standardized and extracted.A database was established for frequency statistics to summarize the distribution characteristics and evolution rules of TCM syndromes and syndrome elements in severe pneumonia.Results:A total of 287 literatures were finally enrolled.After standardization,60 TCM syndrome types were ob-tained,involving 15 disease-nature syndrome elements and 7 disease-location syndrome elements.The predomi-nant syndrome types included syndrome of phlegm-heat obstructing lung,syndrome of interior invasion of patho-gen and vital qi collapse,syndrome of invasion of pericardium by heat,etc.Excessive disease-nature syndrome ele-ments mainly contained heat,phlegm,toxin,wind and blood stasis;deficient disease-nature syndrome elements mainly included qi deficiency,yin deficiency,yang collapse,qi collapse and yang deficiency.The major disease-lo-cation syndrome elements were lung,heart,kidney,pericardium,spleen and large intestine.The core symptoms were cough,rapid pulse,red tongue,slippery pulse,yellow sputum,thirst,fever,dysphoria,yellow and greasy tongue coating.After cluster analysis of syndrome elements,eight common syndrome types were summarized:syndrome of interior invasion of pathogen and vital qi collapse,syndrome of intermin-gled phlegm and toxin,syndrome of spleen deficiency with damp accumulation,syndrome of pathogenic invasion and vital qi insufficiency,syndrome of external pathogen invading lung,syndrome of invasion of pericardium by heart,syndrome of lung heat combined with fu-viscera excess,syndrome of phlegm-heat obstructing lung.Conclusion:The syndromes of severe pneumo-nia are characterized by intermingled excess and deficiency.Phlegm-heat obstructing lung serves as the core pathogenesis.Pathogenic excess such as heat,phlegm,toxin and blood stasis dominates the early stage,while vital qi deficiency including qi deficiency,yin deficiency and yang deficiency prevails in the later stage.